Clinical Neuroscience - 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

The changing face of neuroscience

LORD WALTON of Detchant

This paper is based upon three lectures one given in Australia in a symposiom in honour of Professor James Lance on his retirement, another delivered to the Russian Academy of Medical Sciences on 26 January 1993 and published in the procceedings of that annual symposium of the Academy. It is reproduced here with permission.

ENG 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

The treatment of cluster headache

KARL Ekbom

Cluster headache attacks occur in series, lasting for weeks or months, that are separated by remission periods. However, in less than 15 %, patients suffer from a chronic syndrome, that is regular attacks for one year or longer. The spontaneous course of cluster headache may cause some problems when evaluating clinical trials. For instance, it may be difficult to decide whether an observed improvement is due to effects of the trial drug or to a spontaneous remission. Most studies published hitherto have used an open treatment app- roach – using a concomitant treatment – which is understandable, because the placebo effect has been regarded as being small in cluster headache. In fact, there are in the previous literature only few well-designed, randomised, double-blind clinical trials.

ENG 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Visual P300 and early components in chronic schizophrenic patients (clinical, neurocognitive and biochemical correlates)]

BARTKÓ György, KUNDRA Olga, BOLLA Mariann, ZÁDOR György, SÁNTA Zsuzsa, HORVÁTH Szabolcs, ARATÓ Mihály

[P300 and early components of the visual event related potentials were compared in 26 chronic schizophrenic patients and 20 healthy subjects. The correlation between visual evoked response and clinical, neurocognitive, biochemical variables was analysed in schizophrenic group. Event related potentials in response to rare visual stimuli were recorded from central and occipital sites and 20 electrophysiological parameters were determined. Reaction time and proportion of correct recognition were also detected. The schizophrenic patients showed significant reduction is P300 amplitude. Differences in other components between groups were also demonstrated. The seven most important parameters were evaluated by discriminant analysis. The prolonged negative components latency and delayed reaction time suggest that the stimulus classification process is slower in schizophrenics, Using canonical correlation analysis three factors were found to be significant. The data showed that electrophysiological abnormality was highly correlated with chronicity of the illness, severe psychopathological features and cognitive deficit but was uncorrelated with negative symptoms and serum dopamine-beta-hydroxylase activity. These findings are compatible with other studies suggesting visual P300 has the characteristic of a state marker in schizophrenia.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Intracerebral hemorrhages and their neurosurgical management in early infancy]

PARAICZ Ervin, KÓNYA Eszter

[The number of spontaneous intracerebral hemorrhages over early infancy has increased in the last years in Hungary. As possible cause maybe the lack of Vitamin K prophylaxis in our 19 cases. With regard to management mostly the semiinvasive treatment was succesful, the external drainage of the hemorrhage and CSF. Craniotomy was indicated only in 3 patients. The functional result was good in the majority of cases.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Provocative myasthenia gravis and myasthenic syndromes]

SZOBOR Albert, KLEIN Magda

[Myasthenia gravis as a disease entity has long been known. With the inclusion of the paraneoplastic myasthenia syndrome, a wider area was encompassed by the disease, which became still wider by the description of different myasthenic syndromes in childhood. Recently quite a few provocative factors became known which can cause myasthenia gravis or some similar syndromes. One such-prominent-factor is D-penicillamine a drug widely used in rheumatology practice. A great number of cases were studied involving the provocative factors: D-penicillamine, the infectious diseases, drugs and other possible causes. After provocative factors myasthenia gravis disease, myasthenic syndrome with different clinical course and transitive myasthenic reaction with spontaneous remission may develop. The ability to distinguist between these conditions is important from both the therapeutic and prognostic points of view. Mild not known, or not recognized myasthenia gravis can in some cases be diagnosed by careful neurological examination and diagnostic tests. ]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Characterization of human gliomas by the OITI C3-11 monoclonal antibody]

SIPOS László, TOSHIHIKO Wakabayashi, SZEIFERT György, FAZEKAS Ilona, ÁFRA Dénes

[OITI C3-11 monoclonal antibodies were produced against GFAP positive human glioblastoma tumour cells. The specificity of these antibodies was tested on different type of brain tumours and on normal adult brain both on tissue cultures and paraffin-embedded sections. Such OITI C3-11 monoclonal antibodies reacted with 16 of 18 malignant and 1 of 6 benign gliomas but did not react with meningioma, pituitary, adenoma, metastatic brain tumours and normal adult brain tissue.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[ Lectori salutem! A new class is introduced]

PETŐ Zoltán

[Principles of our thinking. The most important tasks. The purpose of our activity. Our structure and team.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Hungarian Society of Neurologists and Mental Doctors]

[Department of Neurology, Semmelweis University of Medicine and II. After a 5-year break, the Institute of Pathology held a clinicopathology conference at the University II. s. In the classroom of his Gynecology Clinic on November 5, 1993, at 1 p.m. Collective Report on the 9th World Congress of Psychiatry June 6-12, 1993 Rio de Janeiro.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Hungarian EEG and Clinical Neurophysiological Society]

SZIRMAI Imre

[Report on the International Clinical Neurophysiology Society Leadership Election Preparatory Meeting and Management Election Joint Meeting.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[The Hungarian Society of Pediatric Neurology, Neurosurgery, Child and Adolescent Psychiatry]

GYÖRGY Ilona

[The next year's congress of our company will be held on April 7-9, 1994. between Zalaegerszeg. The plan is to start at 11 a.m. Thursday, be interrupted on Friday afternoon by a trip to Göcsej, and continue until noon on Saturday. Our inaugural general meeting will also take place during the meeting.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Hungarian Neurological Society]

VÁRALLYAY György

[Report on the IV. International Congress of Neuroradiology.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Hungarian branch of the International Antiepileptic League]

CLEMENS Béla

[Congressional Report on the 20th International Epilepsy Congress. Report on the MEL forum.]

HUN 1994;47(01-02)

Clinical Neuroscience

JANUARY 20, 1994

[Hungarian Spine Association]

[Scientific activities of the Hungarian Spine Association in 1993. Further plans, ongoing scientific programmes.]

HUN 1994;47(01-02)