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Clinical Neuroscience - 1993;46(11-12)
Content
Clinical Neuroscience
NOVEMBER 20, 1993
[In Memoriam György Bekény]
[After a life of struggle and success, and after a serious illness borne with dignity and discipline, death took him at the age of seventy-eight. Even in the last years of his life, ill but tireless, he served his vocation with his knowledge: healing and teaching; patients and interested students; the Clinic. Shortly before his death, he completed his last scientific work, The History of Hungarian Neurology.]
Clinical Neuroscience
NOVEMBER 20, 1993
[The illogical therapy]
[Most of the causative pathological factors in ischemic cerebrovascular events cannot be recognized during the acute stage of the disease partly because of to the complexity of biophysical model of cerebral microcirculation, partly because the causative factors in this model cannot be confidently weighted. Clinical diagnoses on cerebral circulation disorders are based on the fundamental causes of the disorders. Evoking factors are hypotheses, consequently therapies are directed to hypotheses. The mathematical model of cerebral microcircualtion is mondeterministic. The interactions between vascular factors and blood fluidity can be roughly estimated. Judging the therapeutic efficacy is hindered by the nondeterministic disease model, the indefinite clinical clues, their individual variations, heterogenous diagnostic groups, and tendency of spontaneous restoration of symptoms. Non-specific drugs are used to treat cerebral ischemia, and trials making use of monotherapies have failed to change the life expectancy or the clinical course of ischemic patients. The acute stage of the disease cannot be defined and because of the incompleteness of clinical indicators „stroke prevention" appeares to be ambiguious. Therefore, the nature of the treatment of ischemic cerebrovascular disease is at present based on trial and error.]
Clinical Neuroscience
NOVEMBER 20, 1993
[Molecular characterization of the T cell receptor in experimental allergic encephalomyelitis and multiple sclerosis - new therapeutical approaches]
[The authors review here the most recent literature on experimental allergic encephalomyelitis and multiple sclerosis, focusing on the efferent branch of the immune response. They attempt to describe the molecular characteristics of the myelin antigen specific T cell receptors. Identification of the most distinct properties of the disease mediating cells may not only provide clues to the etiology of MS, but also opens new avenues to specific therapeutical approaches.]
Clinical Neuroscience
NOVEMBER 20, 1993
[Experimential allergic encephalomyelitis multiplex sclerosis!]
[T-lymphocytes and molecular engineering]
Clinical Neuroscience
NOVEMBER 20, 1993
[Transcranial doppler of extracranial stenosis in internal carotid artery]
[Endeavours were made to determine why mean velocity and pulsatility index changes in middle and anterior cerebral artery are caused by the unilateral occlusion of the internal carotid artery or by severe stenosis. The transcranial Doppler method is suitable for judgingre pathologic intracranial blood flow conditions, especially when data are compared to those of healthy conditions.]
Clinical Neuroscience
NOVEMBER 20, 1993
[Imaging of the lumbar synoval cysts]
[Lumbar synovial cysts are infrequent but characteristic manifestations of the commonly encountered but rather complex degenerative disorders affecting the lumbar zygapophyseal joints. The anatomical disposition of the different components of the lumbar motion segment, their sensory innervation and their topographic relationship with the neighbouring nerve structures explain why the neurogical manifestations of these affections, as well as of other articular disorders, cannot always be distinguished from those of discal origin. However, modern imaging methods allow the resolution of the radiological and consequently of the clinical differential diagnostic problems. The systematic use of computed tomography and magnetic resonance imaging in the evaluation of low back pain syndromes has resulted in the recognition and precise description of the practically pathognomonic „radiological syndrome” of the synovial cysts of the lumbar zygapophyseal joints.]
Clinical Neuroscience
NOVEMBER 20, 1993
Multimodality teratment of anaplastic supratentorial gliomas with high-dose dibromodulcitol and dibromodulcitol plus BNCU (a pilot study)
A pilot study with a high dose DBD, and DBD plus BCNU therapy for the treatment of malignant gliomas has been performed. Radiotherapy combined with DBD in a dose of 700 mg/sqm/week was administred to 27 patients after extensive removal of supratentorial anaplastic astrocytomas and glioblastomas. Subsequently, DBD in a dose of 1400 mg/sqm was given monthly to a group of nine patients and another thirteen patients received DBD plus BCNU on two consecutive days in a dose of 1000 mg/sqm and 150 mg/sqm, every 6-8 weeks. Both kinds of chemotherapy have been well tolerated, no patient died because of toxic side effect. Following the first dose of DBD and BCNU such a severe myelotoxicity occurred in one case that treatment was discontinued but the patient recovered completely. The high-dose DBD treatment proved to be markedly effective against glioblastomas, while the combination of DBD and BCNU showed more pronounced activity against anaplastic astrocytomas. As the results were promising, accordingly further extensive studies seem to be worthwhile.
Clinical Neuroscience
NOVEMBER 20, 1993
[Book review]
[Book review of István Barakonyi, József Szántó, János Nikl:Liquor-citodiagnostics in clinical practice]
Clinical Neuroscience
NOVEMBER 20, 1993
[Hungarian Society of Neurologists and Mental Doctors]
[Summary of the IX. Forum of Young Neurologists]
Clinical Neuroscience
NOVEMBER 20, 1993
[Hungarian Society of Neurosurgeons]
[Summary of the 1993 OLIVECRONA lecture by Dr. Emil Pásztor, professor]
Clinical Neuroscience
NOVEMBER 20, 1993
[The Hungarian Society of Pediatric Neurology, Neurosurgery, Child and Adolescent Psychiatry]
[List of participants at the 20th International Congress on Epilepsy]
Clinical Neuroscience
NOVEMBER 20, 1993
[Hungarian branch of the International Antiepileptic League]
[Guidelines for the treatment of women of childbearing age with epilepsy]
Clinical Neuroscience
NOVEMBER 20, 1993
[Hungarian Spine Association]
[Summary of the 1993 Scientific Conference of the Hungarian Spine Society.]
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