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Clinical Oncology

APRIL 30, 2020

[Hormone replacement therapy in cancer survivors – Review of the literature]

DELI Tamás, OROSZ Mónika, JAKAB Attila

[Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insuffi ciency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT). The misinterpretation of the WHI (Women’s Health Initiative) Study has lead to an irrational fear of female hormone replacement, both by the general population and medical professionals. It has seemed the logical and safe conclusion to many physicians to avoid HRT, supposing that this attitude defi nitely causes no harm, whereas the decision of prescribing estrogen alone or with progestins might bear oncologic and thromboembolic risks and may even lead to litigation in case of a potentially related complication. However, it was known even before the WHI results that premature menopause and hypogonadism decreases the life expectancy of women by years through its skeletal and cardiovascular effects, and this negative effect correlates with the length of the hypoestrogenaemic period. Yet, the oncologic risk of HRT is extremely diffi cult to assess. In this work we review the latest evidence from in vitro experiments to clinical studies. We group tumours regarding the oncologic risk of properly chosen female hormone replacement therapy in cancer survivors as follows: ’HRT is advanageous’ (e.g. endometrial cancer type I, cervical adenocarcinoma, haematologic malignancies, local cutaneous malignant melanoma, colorectal cancer, hepatocellular cancer); ’HRT is neutral’ (e.g. BRCA 1/2 mutation carriers without cancer, endometrial cancer type II, uterinal carcinosarcoma and adenosarcoma, certain types of ovarian cancer, cervical, vaginal and vulvar squamous cell carcinoma, prolactinoma, kidney cancer, pancreatic cancer, thyroid cancer); ’HRT is relatively contraindicated’ for various reasons (e.g. leiomyosarcoma, certain types of ovarian tumours, brain tumours, advanced metastatic malignant melanoma, lung cancer, gastric cancer, bladder cancer); ’HRT is diasadvantageous and thus contraindicated’ (e.g. breast cancer, endometrial stroma sarcoma, meningioma, glioma, hormone receptor positive gastric and bladder cancer).]

Lege Artis Medicinae

DECEMBER 15, 2017

[What turns labour pain into suffering? The individual ways of coping]

RADOS Melinda, MÉSZÁROS Judit

[INTRODUCTION - Pain is not only a sensory experience, but includes emotional, motivational and cognitive dimensions, thus women’s perceptions of labour pain are largely influenced by individual attitudes. The distinction between pain and suffering sheds light on valuable information. Our aim was to study the relationship between women’s labour pain and their sense of suffering, and the effects of epidural analgesia on their judgements of pain, stress and satisfaction. SAMPLE AND METHOD - 342 women participated in our study. Their pain was assessed with the Numerical Rating Scale, sense of suffering with the shortened Perceived Stress Scale, which were followed by questions of epidural analgesia administration, its perceived effects and satisfaction. RESULTS - Women’s feelings of pain and sense of suffering show a strong positive correlation (R=0,283, p<0,001); but with the increase of these dimensions their satisfaction decreased (R=-0,162 and R= -0,444 respectively, p<0,001). The administration of epidural analgesia did not have a significant effect on their judgements of pain, stress and satisfaction. Perceived stress had the strongest determining influence on satisfaction (b=-0,534, p<0,001). CONCLUSIONS - According to our results on pain relief, we suggest the wider use of various non-pharmacological methods. Alleviation of maternal fear and suffering through non-judgemental, patient and supportive attitude of caregivers is of paramount importance.]

Journal of Nursing Theory and Practice

FEBRUARY 28, 2017

[Advantages of the bevel down puncture technique]

SOMOSI László, KISS Szilvia, LADÁNYI Erzsébet

[The arterio-venous fistula is also called the dialysis patient’s lifeline. The name lifeline stands for the essential connection between the body and the dialysis machine. Keeping it in good condition is very important, because fistulas play a keyrole in the successful dialysis treatment. Fistula care is indispensable both from the nurse and patient side. The dialysis team is responsible for the fistula puncture and care. We introduced the bevel down puncture technique in November of 2011 for better arterio-venous shunt care. Our dialysis nurses were trained on the correct position of the fistula needle. We emphasised the benefits and long-term effects. We use this technique for all patients, except for the first fistula puncture. The bevel down puncture technique reduces the patient’s fear of fistula puncture as it causes less pain. After removal of the needle, the bleeding time decreased from the approximate 6-7 minutes to less than 5 minutes and bleeding volume is also decreased. It also reduces the size of the scab and the aneurysm formation. In our dialysis unit we have had good experiences with the bevel down puncturing technique, as it kept our patients’ fistulas in good condition, this may prolong vascular accesses lifetime.]

Journal of Nursing Theory and Practice

OCTOBER 30, 2016

[The analysis of influencing factors of population’s participation in colorectal screening programs]

HORVÁTHNÉ KÁNTOR Döniz Vivien

[Aim of the study: The aim of the study was to investigate the influencing factors of participation in screening programs in the population, and to make suggestions to improve the participation rate of these programs. Sample and method: The study was retrospective and not randomised. Self-administered questionnaire was applied among general practitioners’ patients in specific outpatient units of Győr (n=210). SPSS statistical program was used to analyse the data with descriptive and mathematical statistics. Results: 30 % of the sample was male and 70% was female. 50% of the respondents did not know the colorectal screening methods, and only 30% participated in one of them. The reasons of refusal to participate in a screening program were lack of symptoms and fear of the investigation. 94% of the respondents thought that they and other people in their environment could be motivated to participate in the colorectal screening programs. The most effective method was indicated as adequate information about the programs provided by GPs. Conclusions: Our results showed that the given population does not have enough information about colorectal cancer and its screening methods, and several misleading information exists among them, which is resulted in low participation rate of screening programs. ]

Journal of Nursing Theory and Practice

FEBRUARY 28, 2016

[Attitude towards death, psychosomatic and pszichological status of nurses working in hospice care and oncology unit]

NAGY Rebeka, NÉMETH Anikó

[Aim of the research: The aim of the research was to examine the fear of death, the attitudes towards death, the way of processing death, related to the workplace and to assess the burn out and psychosomatic symptoms among oncology nurses and hospice care workers. Research and sampling methods: To execute our research self-developed surveys were distributed online and printed (N=116) in July-August 2015, completed with a control group, as well. For data analysis we used SPSS version 19.0 with the following statistical tests: Chi square test, independent two sample t-test, Spearman rank correlation and variance analysis (p<0,05). Results: Oncology nurses had slightly more positive attitudes towards death, with significant (p=0,034) proneness to concentrate on positive events too, in case of death of their patients, and tend to attend Bálint groups more often (p=0,017), than nurses working in other unists. In the latter group psychosomatic symptoms were more frequent (p=0,032). No significant differences (p=0,234) were found between the groups in cumulative scale of fear of death. Fear of death had great effect on appearance of psychosomatic symptoms (p=0,011) and the extent of burn out (p=0,001). Conclusions: There were no significant differences in fear of death between oncology nurses and hospise care workers.]

Journal of Nursing Theory and Practice

DECEMBER 31, 2013

[The health care changes affected the everyday lives of nurses ]

NÉMETH Anikó, BETLEHEM József, LAMPEK Kinga

[Aims of the study: To examine the changes inpatient care nurses had to undergo following the reorganization of health care system during the last few years. Sample and methods: This was a cross-sectional study conducted in six teaching hospitals of Hungary involving nurses who worked full-time in inpatient care applying self-developed questionnaires between October and December 2010. Results: Nurses had to face many negative events and the feeling of uncertainty during the reorganization, which also affected the self evaluation of their health status. The fear of relocation, reduced salary or losing the job and the worsened psychic status and bad workplace communication are significant. The six-question uncertainty scale can be divided into a promotional and an environmental subscale. Responders expect significant support from their employers, mainly financially. Conclusions: The reorganization of the health care system caused uncertainty by the nurses. ]

Lege Artis Medicinae

SEPTEMBER 22, 2013

[Drug use and death-seeking behaviour attitudes toward death among opiate users]

PAP Ágota, HEGEDÛS Katalin

[Many times, behind mens’ fears there is the fear of death. Drug use can be defined as a kid of self destruction, so it is directly linked to attitudes toward death. In Hungary, suicide among young people is one of the leading causes of death, which is often associated with some kind of addiction or substance abuse. We can also say that drug use is an indirect way of “death search”, which prolongs the agony and the time of suffering. Drug-related death can be directly attributed to drug overdose. Intravenous drug use may cause a risk of infectious diseases (such as sharing needles/syringe/filter use) - HCV, AIDS, etc. Intravenous drug use is mostly - but not exclusively - characteristic to opiate users. Heroin’s mode of action is described as causing an intense feeling of euphoria and a way of feeling augmenting to stupor. Its addictive potential is very high, the degradation is visible and can be fatal. In this paper, we discuss previous observations on overdose that is the validity of harm reduction justified by former research, the possible predictors of overdose and the identification of the prevention area.]

Journal of Nursing Theory and Practice

APRIL 30, 2013

[Does the fear of losing their jobs play any role in the everyday lives of health care workers?]

IRINYI Tamás, NÉMETH Anikó

[Aims: To assess the degree of fear from becoming unemployed among health care workers in Csongrád County, and the impact of this fear on physical and psychic health, or rather the intent to leave the profession. Methods: This is a cross-sectional study carried out through a self-designed self-report questionnaire sent to registered members of MESZK living in Csongrád County. Results: Those with worse psychosomatic status (p=0.003) and greater rate of burnout (p<0.000) are more afraid of losing their jobs. The fear has a great impact on the intent to leave the profession (p<0.000). Who are not afraid of becoming unemployed feel that they would be physically and psychically able to work in their profession till retirement. Conclusions: Fear is present in the everyday lives of health care workers, and affects their physical and psychic health. ]

Clinical Neuroscience

MAY 30, 2013

[Effective, safe stroke prevention with novel oral anticoagulants in patients with atrial fibrillation. Focus on dabigatran]

SZAPÁRY László, FEHÉR Gergely, BOSNYÁK Edit, DELI Gabriella, CSÉCSEI Péter

[Non-valvular AF is the most common cardiac arrhytmia. Its incidence increases with age. AF is an independent risk factor for ischaemic stroke, representing a five times higher risk for it, associated with a high mortality rate. Beside AF, there are several other risk factors which influence the risk of stroke. Stroke risk calculator can be used to assess the risk of patient having a stroke. The most endangered group of patients with AF are those who have already suffered from cerebrovascular event. The only effective medication for prevention of stroke due to AF had been the application of vitamin K antagonists (VKA) which considerably decrease the rate of ischaemic event in a patient with AF providing that the INR is in the therapeutic range. VKA have several limitations of use in clinical practice and the fear of bleeding complications results an underusing of these drugs. Only 50% of all patients treated with VKA reaches the therapeutic range of INR. The breakthrough of prevention of stroke in recent years is undisputedly the coming out of novel oral anticoagulants (NOACs, thrombin and Xa-factor inhibitors). Recent studies suggest that these novel drugs prove the same efficacy as VKA drugs, furthermore dabigatran in a dose of 2×150 mg or apixaban in 2×5mg was statistically superior to warfarin in the prevention of stroke. NOACs have shown a large reduction in intracranial hemorrhage compared with warfarin. They are given as a fixed dose and do not require persistent monitoring making them much more convenient. NOACs at guidelines of European Society of Cardiology act as a preferable drugs in case of ischaemic stroke with AF. Probably the extended use of NOACs in clinical practice will be the mainstream of stroke prevention in the future.]

Journal of Nursing Theory and Practice

OCTOBER 20, 2012

[Epidemic among health care providers: burnout]

IRINYI Tamás, NÉMETH Anikó

[Aims of the study: To track the changes since 2008 in the degree of burnout among health care workers in Csongrád County, and to examine its connections with the evaluation of own health, frequency of psychosomatic symptoms, the intent to leave the profession, and the measure of fear from becoming unemployed. Methodology and sample: This is a cross-sectional study carried out through a self-designed self-report questionnaire sent to registered members of MESZK living in Csongrád County. Results: The number of burned-out health care workers increased since 2008. Burnout correlates with physical health (p<0.000), the intention to leave the profession (p<0.000), and the fear of losing the job (p<0.000). A significant increase could be observed by nurses starting their career. Conclusions: Burnout prevention trainings would be important also by career starters, which could also prevent profession leaving. ]