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Lege Artis Medicinae

NOVEMBER 30, 2020

[GLP-1 receptor agonists in the elderly]

WINKLER Gábor

[According to current guidelines of type 2 diabetes, treatment, glucagon-like pep­tide (GLP) -1 receptor agonists (RAs) are primary suggested drugs of the early antidiabetic medication, just after the first an­ti­­diabetic metformin. However, more and more arguments support their optional application in old age diabetes. These include multi-target strong glycemic ef­fects, low risk of hypoglycaemia, proven cardio- and nephroprotective nature of long- and ultra long-acting derivatives, multifaceted be­neficial pleiotropic effects, as well as the appearence of their fixed combinations with analogue basal insulins effective in weight loss and lowering the blood pressure. This study reviews specific aspects of blood sugar lowering treatment in the elderly and the potential benefits of choosing GLP-1 RAs in this age group. While presenting data of relevant literature and own experiences it is emphasized, that these preparations can be used safely in long term also in this age group.]

Clinical Neuroscience

JANUARY 30, 2020

Valproic acid associated pleuropericardial effusion: case report

DEMIR Figen Ulku

Introduction - Valproic acid is an effective antiepileptic and mood stabilizer used in the treatment of many neurological and psychiatric disorders. Although there are frequently seen side effects, effusions between layers of pleural and pericardial membranes are rare to be seen. Case - Pleuropericardial effusion was detected in a 23 years old woman who was under valproic acid treatment because of epileptic seizure. After 1 year of valproic acid treatment, patient complained of dyspnea. As all the researches intended on etiology were usual, valproic acid has been thought to be responsible for the matter. Control examination after 1.5 months regarding the end of treatment revealed complete recovery of pleuropericardial effusion. Discussion - Pleural and pericardial effusions are rarely seen complications related to the use of valproic acid. It must also be kept in mind that valproic acid causes a potential for such side effects which can be blamed etiologically when the other possibilities for patients are excluded.

Hypertension and nephrology

OCTOBER 23, 2019

[GLP-1 receptor agonists in the treatment of type 2 diabetes]

WINKLER Gábor

[The glucagon-like peptide (GLP)-1 receptor agonists and somewhat later, the sodium-glucose cotransporter (SGLT) -2 inhibitors have brought new perspectives in the antihyperglycemic treatment of type 2 diabetes. The article overviews clinicopharmacologic characteristics of the GLP-1 receptor agonist group, their glycemic and non-glycemic effects, results of the cardiovascular endpoint studies as well as their place in the recent therapeutic guidelines. It is proven, that both glycemic and weight reducing effect is greater of the long-acting (non-prandial) coumpounds as compared to that of the short acting (prandial) derivates, further, that in studies with cardiovascular endpoints they reduced the relative risk of the composite endpoint of non-fatal myocardial infarct, non-fatal stroke and cardiovascular death. Due to the favolurable glycemic and non-glycemic properties their use is advised already in the early course of type 2 diabetes, as combination of the metformin therapy.]

Journal of Nursing Theory and Practice

OCTOBER 30, 2017

[The Prastige and Values of Nurses and Caregivers employed in the Social Service System]

SZŰCS Anett

[Aim of the study: During the study my target was to identify the career motivations, prestige of caretakers and nurses working in the Gödöllő social services and get acquainted with the most important values in their life. Sample and methods: Descriptive type research, number of elements are 81 (n=81). Summarization of the data was executed by Microsoft Office Excel 2007. Results: The employees took part in the research considered their profession as relatively low prestigious, although they would choose again this profession if they could decide again. Supporting professionals consider health, family, friendship and affection as the most important value in their life. Conclusions: The nursesand caretakers interviewed by me consider their choice of career successful in spite of its low prestige and they like their profession. Recognition the values of the employees is an important objective, because the identified values determine the quality of the work they perform.]

Clinical Neuroscience

JULY 30, 2017

[Valproate in the treatment of epilepsy and status epilepticus]

JANSZKY József, TÉNYI Dalma, BÓNÉ Beáta

[According to Hungarian guidelines, valproate - with the exception of infants and small children as well as fertile women - is the first drug of choice in generalized and unclassified epilepsies because it is effective in most seizure types and epilepsy syndromes. It is highly effective in juvenile myoclonic epilepsy. Even though it is not the first-line drug in focal epilepsies, if the first-line therapy is ineffective, it is a plausible alternative as second choice therapy, owing to its different mechanism of action. If the type of epilepsy can’t be surely established, valproate is the drug of choice, as it possesses the broadest-spectrum among antiepileptic drugs. After administration of benzodiazepines, intravenously applied valproate can be a first choice therapy in all types of status epilepticus, owing to its broad-spectrum and efficacy. Valproate is the first-choice therapy in patients with glioblastoma - independently of the seizure type -, as it is likely to improve the survival rate with 2-10 months and the effectivity of chemo- and radiotherapy. Valproate is generally not suggested for fertile women, but - as it is the most effective therapy in some epilepsy syndromes -, the patient has the right to choose valproate therapy, thus undertaking the elevated risk of developmental abnormalities, for higher safety regarding seizures. If only valproate therapy owns the ability to obtain seizure freedom, then stopping its administration is not suggested, but a low dosage has to be aimed (500-600 mg/day, but not more than 1000 mg/day): according to some studies, most idiopathic generalized epilepsies can be controlled by low valproate dosage. Stopping valproate therapy in case of an ongoing pregnancy is not suggested. ]

Lege Artis Medicinae

DECEMBER 18, 2016

[The role of spirituality in the twelve-step treatment model of addicts]

TREMKÓ Mariann, TÓTH András, MOLNÁR Rudolf, PETKE Zsolt

[First of all we shortly present the Minnesota model based on twelve-step programmes that could be implemented effectively in the recovery of addicts. The uniqueness of the model are the involvement of recovering helpers in the therapeutic work and the focus on spirituality. Our essay-like study aims to present the approach of Alcoholics Anonymous which forms the basis of the model, effectivity studies and the potential effect mechanisms through research data. We aim to define the phenomenon of spirituality from different aspects having regard to the preliminary psychological and psychotherapeutical contributions and provide some of our therapeutic tools. In the current study we picture the roles of the professional therapists and the voluntary recovering helpers in our programme. ]

Clinical Neuroscience

NOVEMBER 30, 2016

How to minimize the risk for headache? A lumbar puncture practice questionnaire study

JONATAN Salzer, RAJDA Cecilia, SUNDSTRÖM Peter, MATTIAS Vågberg, VÉCSEI László, ANDERS Svenningsson

Background - To lower the risk for post lumbar puncture (LP) headache the American Academy of Neurology (AAN) recommended using small bore atraumatic needles together with stylet reinsertion in a report from 2005. It is unclear whether these recommendations are followed or not. Objectives - To investigate the diagnostic LP preferences with respect to the AAN guidelines among neurologists by use of a short online questionnaire, and to review previously published literature on the subject. Results - A total of 284 respondents who performed diagnostic LPs completed the questionnaire. Almost half (41%) answered that they always use atraumatic needles. The most common reason (73%) for not using atraumatic needles was that these were not available. Less than half of the respondents who performed LPs had knowledge about the AAN guidelines for diagnostic LPs, and 48-76% agreed with the different recommendations therein. Five previously (1998-2015) published studies investigating LP practice among neurologists were identified. The reported frequency of atraumatic needle use (always/routinely) varied between 2 and 16%. Discussion - Atraumatic needle use was more common in this study compared with previous publications. There is still skepticism regarding some of the AAN recommendations, and needle availability appears to be the most important factor preventing atraumatic needle use. To increase the use of atraumatic needles we may perform additional studies investigating their potential benefits, and arrange training sessions for neurologists to increase their awareness and level of comfort with the atraumatic LP technique.

Journal of Nursing Theory and Practice

APRIL 30, 2015

[The role of self-help groups in the treatment of alcoholism]

PRÍMA Erika

[Alcoholism is one of the best-known addictions. The results of both international and national surveys illustrate the health consequences of the excessive consumption of alcoholic beverages, and its link with alcoholic disease and the associated dangers, but we still find a high proportion of people who show unrestrained consumption. Is there a genuine desire to recover, is there motivation, and where should one look for help? Such assistance could take the form of a self-help group, where addicts who want to quit, those in the various stages of recovery, or those who have already recovered, can meet up. The aim is to achieve and maintain abstinence, and prevent a relapse. The author presents the process and benefits of self-help, from the perspective of addiction. Her study proves that the treatment of alcoholism requires a complex approach, and one in which we can ascribe a key role to self-help groups.]

Journal of Nursing Theory and Practice

FEBRUARY 28, 2014

[Can be taught first aid for children 5-6 years old?]

BÁNFAI Bálint, RADNAI Balázs, MARTON József, PÉK Emese, DEUTSCH Krisztina, BETLEHEM József

[Aims of the study: Basic Life Saving Activities should be thought in early childhood in order to base helping aptitude for adulthood. The authors’s aim was to teach kindergarten children for basic first aid duties and than to examine their results. Sample and methods: 51 children were involved in the survey. There was two sessions with theoretical and practical games about first aid. On the third session children were tested about their skills and one month later re-tested. The statistical analyses were made with SPSS 17.0 software. Results: The maximum point of the test was 38 points. The average point of the first test was 16,94 points and the re-test score was higher. The difference between the results was significant (p<0,05). The results showed attitudinal differences between boys and girls (p<0,05). Conclusions: The 5 and 6 years old children of kindergarten can learn the basic concepts. ]

Lege Artis Medicinae

MARCH 20, 2014

[Meet the new member of the alprazolam family]

FERENCZ Csaba

[The struggle against anxiety disorders and symptoms of anxiety is as old as the history of human healing. The development of anxiolytics has constituted an important field of pharmacology from the very beginning. The appearance of benzodiazepines and high-potential benzodiazepines, developed as a later evolution of the former compounds, is considered a milestone in this battle. Today alprazolam is their most widely-used representative that can be considered a golden standard. Besides its agent, the formulation of the drug is also significant, as it helps in the administration, absorption and bioavailability of the agent and even for the establishment of good compliance. Nowadays we can witness the development of medicine families containing the same active ingredient and consisting of various products. In the case of alprazolam, we can welcome a new member of the family following the immediate-release tablets and the extended-release tablets. The aim of this paper is the introduction of the new member of the alprazolam family: the sublingual tablet.]