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FEBRUARY 23, 2012

Is salt more healthier if you buy it from a pharmacy? Facts, delusions and controversies about sodium chloride.

TAKÁCS Gábor, FITTLER András, BOTZ Lajos

Misleading information was disseminated on the internet about the contamination of commercial salt with great, thus toxic quantities of potassium chloride. In our study commercial salt samples were analyzed and potassium content was below 0,2% in regular salt samples. Homeostatic regulation of sodium and potassium was reviewed. Current concepts about the optional daily intake of these important electrolytes and fats regarding the correlation between salt intake and hypertension were discussed.

Clinical Neuroscience

MARCH 20, 2007

[CENTRAL ATRIAL NATRIURETIC PEPTIDE IN DEHYDRATION]

BAHNER Udo, GEIGER Helmut, PALKOVITS Miklós, LENKEI Zsolt, LUFT C. Friedrich, HEIDLAND August

[To test the effect of dehydration on brain atrial natriuretic peptide (ANP) concentrations in areas important to salt appetite, water balance and cardiovascular regulation, we subjected rats to dehydration and rehydration and measured ANP concentration in 18 brain areas, as well as all relevant peripheral parameters. Water deprivation decreased body weight, blood pressure, urine volume, and plasma ANP, while it increased urine and plasma osmolality, angiotensin II, and vasopressin. ANP greatly increased in 17 and 18 brain areas (all cut cerebral cortex) by 24 h. Rehydration for 12 h corrected all changes evoked by dehydration, including elevated ANP levels in brain. We conclude that chronic dehydration results in increased ANP in brain areas important to salt appetite and water balance. These results support a role for ANP as a neuroregulatory substance that participates in salt and water balance.]

Clinical Neuroscience

MARCH 20, 2007

[PITUITARY ATRIAL NATRIURETIC PEPTIDE OF PARAVENTRICULAR NUCLEUS ORIGIN]

FODOR Mariann, MAKARA B. Gábor, PALKOVITS Miklós

[Atrial natriuretic peptide-synthesizing neurons in the hypothalamic paraventricular nucleus constitute the major sources of ANP in the three lobes of the pituitary gland. Complete transection of the pituitary stalk eliminated 93% of ANP from the intermediate lobe, 47 and 77% from the anterior and the posterior lobes, respectively. Meantime, increased levels of immunoreactive ANP were measured in the median eminence, due to the accumulation of the peptide in the transected axons centrally to the transected stalk and in the paraventricular nucleus. It is likely that ANP neurons in the paraventricular nucleus innervate the pituitary, but those in the periventricular (median) preoptic nucleus and the organum vasculosum laminae terminalis may not contribute to the ANP innervation of the pituitary gland.]