Lege Artis Medicinae

[THE ROLE OF SIMVASTATIN IN THE TREATMENT OF DIABETIC DYSLIPIDAEMIA]

BALOGH Zoltán, PARAGH György

MARCH 19, 2007

Lege Artis Medicinae - 2007;17(03)

[Patients with type 2 diabetes have markedly increased cardiovascular morbidity and mortality. Type 2 diabetes is typically associated with atherogenic dyslipidaemia, which is characterized by elevated triglycerides, low plasma levels of high-density lipoprotein cholesterol, and an increased ratio of small, dense lowdensity lipoprotein particles. Current treatment guidelines stress the importance of lipidlowering therapy in reducing cardiovascular risk in diabetic patients. Statins currently represent the cornerstone of dyslipidaemia management, based on their ability to efficiently reduce cardiovascular risk through lowering low-density lipoprotein cholesterol. They have, however, a relatively modest effect on the components of atherogenic dyslipidaemia, since they reduce triglycerides by only 15 to 35% and elevate high-density lipoprotein cholesterol by less than 10%. This raises the need for combining statins with other lipid-lowering drugs (ezetimibe, nicotinic acid, fibrate) at an early stage of type 2 diabetes. Authors review the role of simvastatin monotherapy in the treatment of diabetic dyslipidaemia and summarize the results of studies on simvastatin as part of a combined lipid-lowering treatment.]

COMMENTS

0 comments

Further articles in this publication

Lege Artis Medicinae

[19th World Congress of Diabetology]

HIDVÉGI Tibor

Lege Artis Medicinae

[The initial symptoms of severe sepsis - A multidisciplinar diagnostic guideline by the Hungarian Sepsis Forum for the reduction of hospital mortality from septic processes]

BOGÁR Lajos, LUDWIG Endre

Lege Artis Medicinae

[Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatography]

CZAKÓ László, TAKÁCS Tamás

Lege Artis Medicinae

[Endocrinology in the focus - Readers’ questions answered by professor dr. Edit Gláz and dr. Péter Igaz]

GLÁZ Edit, IGAZ Péter

Lege Artis Medicinae

[Cooperation of the cytopathologist and the radiologist in cytodiagnostics]

JÁRAY Balázs, SZÉKELY Eszter, ISTÓK Roland, WINTERNITZ Tamás, TARJÁN Zsolt, TÓTH Anna, GYŐRI Gabriella, PÉNTEK Zoltán, EGYED Zsófia, NÁDOR Katalin

All articles in the issue

Related contents

Lege Artis Medicinae

[30 years in diabetology reflected on the pages of Lege Artis Medicinae – 1990-2020]

WINKLER Gábor

[Commemorating the 30th anniversary of foundation the journal Lege Artis Me­di­cinae, the author endeavours to review the main developments of diabetology in the same period and arranges their reflections on the journal’s pages. He points out that similar to many other disciplines, the history of development has extremely been rich in the past three decades, thus he focused only on a few issues. The author analyses the changes in the treatment of type 2 diabetes and highlights specific aspects like the importance of early metabolic control, individualized treatment choices, a risk-oriented approach instead of a glucocentric direction, and the role of patient education and a health-conscious lifestyle, which have resulted in the holistic approach of our therapeutic strategy. While using relevant quotes, the author shows that the readers of the journal were also able to keep pace with all events and they were always provided with relevant information by au­thentic specialists of diabetology. ]

Lege Artis Medicinae

[Self-monitoring of blood glucose in type 2 diabetes]

POZSÁR Hajnalka, POZSÁR Csaba

[Self-monitoring of blood sugar levels is an essential element in the treatment of diabetes, it provides an insight to the success of treatment and self-management, the development of metabolic processes, and ensures the early recognition and treatment of significant blood sugar fluctuations. The aim of this study was to evaluate the habits of self-monitoring of sugar levels in patients with type 2 diabetes, and among them the frequency, recognition and treatment of hypo- and hyperglycemia. The research was conducted as a cross-sectional study in 2018 in the Health Centre in Subotica/Serbia. The sample included 107 patients diagnosed with type 2 diabetes. Data were collected through interviews with patients using a customized questionnaire, during the regular control examinations. The patients’ level of blood sugar in the capillary blood was measured by glucometer. The statistical package IBM-SPSS 20.0 and descriptive analytic methods were used for data analysis. The mean age of the sample was 63.7 ± 7.7 years. Two-thirds of them performed opportunistic self-monitoring mostly before breakfast. A large number of patients never recognized variations of blood glucose (in 65% hyperglycemia and in 51% hypoglycemia). However, a month before 81% of patients had hyper- and 31% hypoglycemic episodes respectively. 12% of patients did not take any action in such cases. It is recommended to emphasize again and again the importance and way of self-monitoring at each follow-up examination. The shortcomings identified in the study provide guidelines what to focus on when caring for diabetic patients.]

Lege Artis Medicinae

[THE WORLDWIDE EPIDEMIC OF TYPE 2 DIABETES - CAUSES AND CONSEQUENCES]

JERMENDY György

[The prevalence of type 2 diabetes mellitus has recently dramatically increased worldwide. While many factors contribute to the startling data, including changes in the diagnostic criteria of glucose intolerance, increase of life expectancy, manifestation of diabetes at younger ages, and increased detection of unrecognized diabetes due to more efficient screening, the genuine, steep rise in the incidence of diabetes is explained by the increasing prevalence of obesity. Among the late complications of both diabetes and obesity, cardiovascular diseases are particularly important. Insulin resistance due to visceral obesity plays a central role in the pathomechanism of type 2 diabetes. In the prevention of both type 2 diabetes and obesity, non-pharmacological intervention such as life style changes should be considered first. Supplementary pharmacological treatment should target all cardiovascular risk factors.]

Lege Artis Medicinae

[Antidiabetic therapy of patients with type 2 diabetes - The role of incretin mimetics]

GERŐ László

[Incretin mimetics represent a new group of antidiabetic drugs. They bind to their own receptor on the beta-cell membrane and increase insulin secretion in a glucosedependent manner. Thus, they rarely cause hypoglycaemia. Furthermore, they significantly reduce body weight and other cardiovascular risk factors. Accordingly, they can be considered as an optimal group of antidiabetic drugs. The author reviews the clinical efficacy and safety of currently available incretin mimetics.]

Image challenge

What do you see on the feet of the diabetic patient?