Lege Artis Medicinae

[The role of measuring galactomannan in the modern therapy of invasive aspergillosis]


SEPTEMBER 20, 2011

Lege Artis Medicinae - 2011;21(08-09)

[Invasive aspergillosis is a life threatening mycosis prevalent in groups of patients with specific risk factors. To establish the diagnosis a specimen for histological examination has to be obtained. However, the vast majority of patients are not suitable for biopsy or this procedure can only be performed late in the course of the disease. Current diagnostic workup is based on high resolution thoracic CT scans and serum galactomannan antigen testing. Antigen detection can either be used for screening to detect early phase infection or to prove the full-blown disease. Here clinical aspects of galactomannan antigen testing and its role in current management of aspergillosis are reviewed.]



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