Lege Artis Medicinae

[The count, the count drowned, or the debate on the social security budget in the Parliamentary Committee]


FEBRUARY 09, 1991

Lege Artis Medicinae - 1991;1(03)

[It is a peculiar, but familiar journalistic task for newspapers "condemned to a long print run" to report on the preparatory work of events - in this case, turnovers - in such a way that the interested public can already know the outcome from the daily papers: the miracle or mouse that the mountains were in labour before the eyes of the correspondent. Perhaps it is not uninteresting to learn about the debates, the ideas and the institutional, political and personal conflicts - often more important than the final outcome - that emerge and which will determine not only the decisions taken now, but also the foreseeable future.]



Further articles in this publication

Lege Artis Medicinae

[The role of computer tomography and magnetic resonance imaging in organic neurological diagnosis]

KENÉZ József

[In the last two decades, neuroimaging became the basic investigative method in the diagnostics of organic neurology due to the rapid development of medical electronics. In the nineties called the "Decade of the Brain", the importance of these methods could hardly bee overestimated. The two outstanding investigations of neuroimaging are computer tomography (CT) and magnetic resonance imaging (MR). Surely in the near future the application of these investigations will be incorporated in the Hungarian healthcare system as well. In this review all the points of view are collected on the basis of neurologic clinical symptomatology to help clinicians to decide, which method and when has to be chosen to gain the most valuable and detailed information on the quickest way, with less risk, and for the least amount of money ]

Lege Artis Medicinae

[Awareness of hypoglycaemia in diabetes mellitus: Prospective clinical-epidemiological investigations]


[In order to survey the frequency of hypoglycaemia and its awareness we investigated 91 insulin- treated diabetic women (48 pregnant and 43 non-pregnant) consecutively using 9 to 15 blood glucose measurements. Subjective hypoglycaemic symptoms of patients were registered by using a structured questionnaire. Biochemically proved hypoglycaemia has been found in two third of patients (62/91). One third of the patients had a loss of awareness, 23 had partial awareness and 19 were aware of hypoglycaemia. No significant difference were found according to age, diabetes duration, daily insulin dose/kg body weight, glycated haemoglobin levels and frequency of diabetic complications. Five standard cardiovascular autonomic reflex-tests were performed in 31 patients. Age, diabetes duration, frequency of diabetic complications of patients with evidence of autonomic neuropathy significantly surpassed that of having normal cardiovascular reflex-tests. Our results confirm from clinical-epidemiological aspect that hypoglycaemia unawareness is not invariably associated with cardiovascular autonomic neuropathy. ]

Lege Artis Medicinae

[Five cases of operated atrial tumors]


[Between November 1986. and June 1989. five patients underwent excision of an atrial tumour. Two of the patients had previous peripheral embolization, two had cardiac symptoms and one was symptomless. All the tumours were demonstrated by means of echocardiography and in four cases by angiocardiography as well. Four of them were left atrial tumors and one in the right atrium. The tumors were succesfully removed in all patients: in three cases by shaving them from the endocardium, in one case by excising a portion of atrial septum and in one case with a margin of normal atrial wall. Histological examination showed thrombus in one case. All patients survived operation and left hospital in good conditions. During the follow up there were no cardiac complication or local recurrence.]

Lege Artis Medicinae

[Hypothesis of natural birth]


[It's supposed by the author that there exists a natural birth. According to his assumption in every woman's subconscionsness there is the code of the natural birth's behaviour (CODE), which can be spontaneously mobilized in the gravid woman. Putting into practice whichever way for the preparation of the birth, this mobilization can be advanced and in this way the child-bearing women's behaving repertory during their birth is increasing and it's drawing near to the equivalent of its own code. This may be the explication of the success and result of the alternative obstetrics end the preparing programs for the different births. The psychological explanation of the theory is given on the basis of C. G. Jung's activity.]

Lege Artis Medicinae

[Report on gastroenterological endoscopic activity in Hungary in 1989]

NAGY György, JUHÁSZ László

[The Endoscopic Section of the Hungarian Gastroenterological Society, under the leadership of Professor Wittmann, published an annual report on the status and development of endoscopy of the digestive organs in Hungary from 1975. In 1976, the report reported 27453 examinations performed at 75 endoscopic workplaces with 163 instruments. The 1987 survey already included 139496 examinations (36623 in Budapest, 102873 in the countryside) performed at 117 workplaces (37 in Budapest, 80 in the countryside) with 565 instruments (219 in Budapest, 346 in the countryside). In a statistical summary of 13 years, 968090 endoscopic examinations resulted in 389 (0.4 per thousand) complications, of which 71 (7 per 100,000) were fatal. The collection of study data was interrupted with the death of Professor Wittmann. ]

All articles in the issue

Related contents

Lege Artis Medicinae

[A short chronicle of three decades ]


[Hungarian professional periodicals started quite late in European context. Their publish­ing, editing and editorial philosophy were equally influenced by specific historical and political situations. Certain breaking points of history resulted in termina­tion of professional journals (War of In­de­pendence 1848-1849, First and Se­cond World Wars), however there were pe­riods, which instigated the progress of sciences and founding of new scientific journals. Both trends were apparent in years after the fall of former Hungarian regime in 1990. The structure of book and journal publishing has changed substantially, some publishers fell “victim” others started successfully as well. The latters include the then-established publishing house Literatura Medica and its own scientific journal, Lege Artis Me­di­cinae (according to its subtitle: New Hun­garian Medical Herald) issued first in 1990. Its appearance enhanced significantly the medical press market. Its scientific publications compete with articles of the well-established domestic medical journals however its philosophy set brand-new trends on the market. Concerning the medical community, it takes on its problems and provides a forum for them. These problems are emerging questions in health care, economy and prevention, in close interrelation with system of public health institutions, infrastructure and situation of those providing individual health services. In all of them, Lege Artis Medicinae follows consequently the ideas of traditional social medicine.]

Clinical Neuroscience

[Consensus statement of the Hungarian Clinical Neurogenic Society about the therapy of adult SMA patients]

BOCZÁN Judit, KLIVÉNYI Péter, KÁLMÁN Bernadette, SZÉLL Márta, KARCAGI Veronika, ZÁDORI Dénes, MOLNÁR Mária Judit

[Background – Spinal muscular atrophy (SMA) is an autosomal recessive, progressive neuromuscular disorder resulting in a loss of lower motoneurons. Recently, new disease-modifying treatments (two drugs for splicing modification of SMN2 and one for SMN1 gene replacement) have become available. Purpose – The new drugs change the progression of SMA with neonatal and childhood onset. Increasing amount of data are available about the effects of these drugs in adult patients with SMA. In this article, we summarize the available data of new SMA therapies in adult patients. Methods – Members of the Executive Committee of the Hungarian Clinical Neurogenetic Society surveyed the literature for palliative treatments, randomized controlled trials, and retrospective and prospective studies using disease modifying therapies in adult patients with SMA. Patients – We evaluated the outcomes of studies focused on treatments of adult patients mainly with SMA II and III. In this paper, we present our consensus statement in nine points covering palliative care, technical, medical and safety considerations, patient selection, and long-term monitoring of adult patients with SMA. This consensus statement aims to support the most efficient management of adult patients with SMA, and provides information about treatment efficacy and safety to be considered during personalized therapy. It also highlights open questions needed to be answered in future. Using this recommendation in clinical practice can result in optimization of therapy.]

Clinical Neuroscience

[The importance of patient reported outcome measures in Pompe disease]

MOLNÁR Mária Judit, MOLNÁR Viktor, LÁSZLÓ Izabella, SZEGEDI Márta, VÁRHEGYI Vera, GROSZ Zoltán

[In recent decades it has become increasingly important to involve patients in their diagnostic and treatment process to improve treatment outcomes and optimize compliance. By their involvement, patients can become active participants in therapeutic developments and their observations can be utilized in determining the unmet needs and priorities in clinical research. This is especially true in rare diseases such as Pompe disease. Pompe disease is a genetically determined lysosomal storage disease featuring severe limb-girdle and axial muscle weakness accompanied with respiratory insufficiency, in which enzyme replacement therapy (ERT) now has been available for 15 years. In our present study, patient reported outcome measures (PROMs) for individuals affected with Pompe disease were developed which included questionnaires assessing general quality of life (EuroQoL, EQ-5D, SF36), daily activities and motor performance (Fatigue Severity Score, R-PAct-Scale, Rotterdam and Bartel disability scale). Data were collected for three subsequent years. The PROM questionnaires were a good complement to the physician-recorded condition assessment, and on certain aspects only PROMs provided information (e.g. fatigue in excess of patients’ objective muscle weakness; deteriorating social activities despite stagnant physical abilities; significant individual differences in certain domains). The psychological effects of disease burden were also reflected in PROMs. In addition to medical examination and certain endpoints monitored by physicians, patient perspectives need to be taken into account when assessing the effectiveness of new, innovative treatments. With involvement of patients, information can be obtained that might remain uncovered during regular medical visits, although it is essential in determining the directions and priorities of clinical research. For all orphan medicines we emphasize to include patients in a compulsory manner to obtain general and disease-specific multidimensional outcome measures and use them as a quality indicator to monitor treatment effectiveness.]

Clinical Neuroscience

Cyanocobalamin and cholecalciferol synergistically improve functional and histopathological nerve healing in experimental rat model

ALBAY Cem, ADANIR Oktay, AKKALP Kahraman Asli, DOGAN Burcu Vasfiye, GULAEC Akif Mehmet, BEYTEMUR Ozan

Introduction - Peripheral nerve injury (PNI) is a frequent problem among young adults. Hopefully, regeneration can occur in PNI unlike central nervous system. If nerve cut is complete, gold standard treatment is surgery, but incomplete cuts have been tried to be treated by medicines. The aim of the study was to evaluate and compare clinical and histopathological outcomes of independent treatment of each of Vitamin B12 (B12) and Vitamin D3 (D3) and their combination on sciatic nerve injury in an experimental rat model. Materials and methods - Experimental animal study was performed after the approval of BEH Ethics Committee No. 2015/10. 32 rats were grouped into four (n=8) according to treatment procedures, such as Group 1 (controls with no treatment), Group 2 (intraperitoneal 1 mg/kg/day B12), Group 3 (oral 3500 IU/kg/week D3), Group 4 (intraperitoneal 1 mg/kg/day B12+ oral 3500 IU/kg/week D3). Sciatic Functional Index (SFI) and histopathological analysis were performed. Results - SFIs of Group 2, 3, 4 were statistically significantly higher than controls. Group 2 and 3 were statistically not different, however Group 4 was statistically significantly higher than others according to SFI. Axonal degeneration (AD) in all treatment groups were statistically significantly lower than in Group 1. AD in Group 4 was significantly lower than in Group 2 and 3; there was no significant difference between Group 2 and 3. There was no significant difference between Group 1,2 and 3 in Axonolysis (A). But A of Group 4 was significantly very much lower than all others. Oedema- inflammation (OE-I) in all treatment groups were significantly lower than in Group 1; there was no significant difference between Group 2 and group 4. OE-I in Group 2 and 4 were significantly lower than in Group 3. There were no significant differences between Group 1, 2 and 3 in damage level scores; score of Group 4 was significantly lower than of Group 1. Conclusions - B12 and D3 were found effective with no statistically significant difference. But combined use of B12 and D3 improve nerve healing synergistically. We recommend combined use of B12 and D3 after PNI as soon as possible.

Lege Artis Medicinae

[Tobacco use habits and cessation support tasks in Hungary. PART 1.]

CSELKÓ Zsuzsa, FÉNYES Márta, CSÁNYI Péter, BOGOS Krisztina, KISS Judit, DEMJÉN Tibor

[Today, non-communicable diseases and their underlying main risk factors, namely tobacco use, physical inactivity, excessive alcohol intake and unhealthy diet are responsible for almost 70% of the mortality worldwide. The Global Ac­tion Plan issued for the preven­tion and control of non-communicable diseases aims among others to reduce smoking rates by 30% as compared to the 2010 prevalence. The aim of the World Health Or­ga­ni­zation (WHO) in ac­cor­dance with the United Nations Sus­tai­nable Development Goals (UN SDG 2030) proposes to achieve a 23% target rate in Hun­gary by 2025. Based on the current smo­king prevalance (29%) and preliminary estimates this goal will not be accomplished. It is highly concerning that while the con­sumption of traditional tobacco products does not decrease at the expected rate in Hungary, novel nicotine and tobacco products are spreading worldwide and in Hungary as well. Thus in order to curb tobacco use, more ro­bust actions are needed in Hungary. More emphasis should be laid on the provisions of the WHO Fra­mework Con­vention on Tobacco Control (FCTC). This document re­com­mends to in­crease the tax rate of to­bacco products, declares to halt the spread of novel nicotine and tobacco products, and urges health care requirements to support smokers in quit­ting. The present summary describes the smoking cessation support related tasks of the health care in­dust­ry, taking into ac­count current national smoking habits. ]