Lege Artis Medicinae

[The biological basis of screening: natural history of malignous tumours]


NOVEMBER 22, 2012

Lege Artis Medicinae - 2012;22(10-11)

[The development of malignous tumours is a prolonged, multistage process. The onset of clinical symptoms and subjective complaints is preceded by the preclinical detectable phase, during which the tumour does not cause any symptoms but it has some signs and can be detected by screening. Information on the tumour’s natural history is of practical importance for choosing the screening strategy. When evaluating screening results, the various biases related to biological reasons need to be taken into consideration.]



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