Lege Artis Medicinae

[So That’s What it is About!?]

GRÉTSY Zsombor

SEPTEMBER 15, 2006

Lege Artis Medicinae - 2006;16(08-09)

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Lege Artis Medicinae

[RHEUMATIC DISEASES AND MALIGNANCIES - PARANEOPLASTIC SYNDROMES]

SZEKANECZ Éva, ANDRÁS Csilla, KISS Emese, TAMÁSI László, SZÁNTÓ János, SZEKANECZ Zoltán

[Numerous malignancies may be associated with musculoskeletal symptoms. In paraneoplastic syndromes, the rheumatic disease is related to the tumour development and the removal or treatment of the underlying malignancy results in the improvement of rheumatic symptoms. Sometimes it is the bad responsiveness of the rheumatic disease to conventional therapies that calls the attention to an underlying malignant condition. Therefore, in case of an unusual disease course a thorough search for malignancies is indicated. The authors give a thematic review on the most common paraneoplastic rheumatic syndromes and discuss the general diagnostic and therapeutic guidelines.]

Lege Artis Medicinae

[BREAST CANCER CARE: FROM PREVENTION TO SURVEILLANCE]

KAHÁN Zsuzsanna

[Breast cancer is the most common malignancy in women in developed countries. The development of most breast cancers is related to various hormonal effects, while 10% is associated with inherited gene mutations. Most of the primary prevention methods aim at decreasing the effects of hormones, but education on proper lifestyle is also an important risk-lowering method. The primary treatment of early breast cancer is usually breast-conserving surgery, either with the targeted removal of regional lymph nodes (by sentinel lymph node labelling) or with axillary block-dissection. The aim of postoperative radiotherapy is the eradication of the tumour cells left behind. Beside the locoregional tumour control this also plays a role in the prevention of recurrence or a secondary systemic dissemination. Adjuvant systemic treatments are used for the eradication of disseminated microscopic tumour foci. The use of modern adjuvant treatments may reduce death from the disease by up to 50%. The risks of relapse or death may be estimated based on established prognostic factors. While in low-risk patients it is not worth starting medical treatment, especially in view of the side effects, while in other cases chemo- or hormonal therapy may save the patient's life. The choice of the medical treatment should also depend on the patient's general health, the concomittant diseases and her preferences. The collaboration of the various specialists involved in the care of breast cancer patients can best take place at specialised breast centres that are equipped with the necessary technical basis, knowledge and professional experience.]

Lege Artis Medicinae

[THE ROLE OF INTRA-ABDOMINAL OBESITY IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASE]

ZÁMOLYI Károly

[Obesity, particularly intra-abdominal (visceral) obesity, is a leading cause of cardiovascular disease, insulin resistance, type 2 diabetes, dyslipidaemia, and thrombosis. There is a growing consensus that abdominal obesity, measured by wait circumference, is a better predictor of coronary artery disease, diabetes and metabolic syndrome than body mass index. Although the primary function of adipocytes is storage and release of energy, several factors secreted by adipocytes have regulatory roles in metabolism and exert vascular effects. The pro-inflammatory adipokines, for example, play a causal role in the development of insulin resistance, type 2 diabetes and cardiovascular disease. Clinical studies provide growing evidence that adipous tissue is biologically highly active and possesses a range of metabolic and endocrine functions. The aim of this review is to explore the pathophysiological connections between abdominal obesity and the development of cardiovascular diseases.]

Lege Artis Medicinae

[Competency list of the general practice, 2005]

KRAMER Imre

Lege Artis Medicinae

[The Memorial of Géza Csáth]

KRAMER Imre

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