Lege Artis Medicinae

[Role of oxygen derived free radicals during myocardial reperfusion]

KÓNYA László 1, FEHÉR János1, JUHÁSZ Nagy Sándor2

DECEMBER 25, 1991

Lege Artis Medicinae - 1991;1(18)

[Oxygen derived free radicals are now considered to be important contributors to tissue (myocardium) injury associated with ischemia and reperfusion. Normaly the tissue concentration of these toxic intermediate products of oxygen is strietly limited, but production of oxygen free radicals overwhelming the capacity of the tissue elimination may cause serious damage. Thus reperfusion has it's own danger with the extension of the injury produced by the ischemia alone. Several experi mental studies have shown that different free radical scavengers can reduce the post-ischemic tissue injury, however, there are contradictory results and unresolved problems. Further investigation is necessary to establish the relevance of oxygen free radical mediated myocardial injury and the effective antioxidant treatment. ]

AFFILIATIONS

  1. Semmelweis Orvostudományi Egyetem II. sz. Belgyógyászati Klinika Budapest
  2. Semmelweis Orvostudományi Egyetem Ér- és Szívsebészeti Klinika Budapest

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