Lege Artis Medicinae

[Risk of BCG immunotherapy for superficial bladder tumours: sideeffects and complications]

SOMOGYI László1, POLYÁK László1, SZÁNTÓ Árpád1

MAY 26, 1993

Lege Artis Medicinae - 1993;3(05)

[The treatment of superficial bladder tumours cannot be confined to surgical removal of the malignancy, due to the high rate of recurrence. The prevention of tumour recurrence is also an essential part of the treatment. Side effects and complications of BCG immunotherapy mounted on 152 patients are summarized. Diagnostic procedures and prevention of failures are discussed. Although the side-effects cannot be ignored, the authors express that the therapeutic advantage to adjuvant bladder treatment rises over the hazard of the toxic side-effects. A yearly repeated treatment cycle leads to not more complications than a single six-week course itself. ]

AFFILIATIONS

  1. Pécsi Orvostudományi Egyetem Urológiai Klinika

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[Multiple regulatory mechnanisms are activated wit hin the immune system to maintain the homeostasis of the organism. A key element of these processes is the specific recognition of antigens mediated by T and B lymphocytes. This is the basis of clonal selection and antigen specific activation of the immune system (LAM 1991. 1(18):1308–1314.) which results in the most efficient elimination of the antigen. T cells play a predominant role in the discrimination of self and non-self structures. Antigen specific activation of T cells results in the expression of cell surface molecules and in the production of different lymphokines of high biological activity, which define the possibilities for cell to cell interactions and influence the function of different cell types affecting the outcome of the immune response. The appropriate activity of functionally distinct T cells enables the most efficient mobilization of effector mechanisms leading to the elimination of the antigen without destroying self components. In order to exert their regulatory and effector functions they require a well regulated collaboration with antigen presenting cells. This review summarizes our present knowledge on the intracellular degradation and transportation pathways occuring on in antigen presenting cells determining the antigen specific functions of T cells. It is well established that these events influence the efficacy or protection against pathogens and have a basic influence on the normal or pathological outcome of autoimmunity.]

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[The Social Security Health Insurance Fund's Mental Hygiene Board of Trustees]

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