Lege Artis Medicinae

[Patient advocacy and quality control in health care work - Concerns]

BUDA Béla

JANUARY 12, 1991

Lege Artis Medicinae - 1991;1(01)

[Over the last 25 years or so, the American medical sociologist Eliot Freidson (and many others in his wake) has argued in a series of books and articles that there is a growing tension in modern society between the traditional need for professional autonomy and the isolation of doctors from any external social quality control of medical and health work. ]

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Further articles in this publication

Lege Artis Medicinae

[Current issues in oral anticoagulation treatment]

SAS Géza

[Cardiovascular disease is the leading cause of death in civilised countries everywhere. The situation is particularly serious in our country: it is well known that we are one of the countries with the shortest life expectancy in Europe, precisely because of the devastating impact of circulatory diseases. While in the USA, thanks to improvements in living conditions and effective preventive measures, mortality from cardiovascular disease is falling dramatically and is being postponed to later and later years, here at home we can unfortunately expect the situation to deteriorate further in the years ahead.]

Lege Artis Medicinae

[The importance of oral symptoms in the early diagnosis of HIV infection (AIDS)]

BÁNÓCZY Jolán

[Oral lesions of AIDS might occur in every phase of H/V-infection, their importance in the early diagnosis and treatment is significant. The most frequent oral symptoms are: oral Candidiasis, acute necrotizing ulcerative gingivitis (ANUG) and periodontitis, herpetic infections, resistent to the usual therapy. ,,Hairy leukoplakia " of the tongue is characteristic hyperpigmentation of the oral mucosa, Kaposi's sarcoma are frequent symptoms, latter especially in more developed phases (ARC or AIDS) of the disease. Saliva-containing a factor inhibiting HIV-1 infection of human lymphocytes - has minimal importance in the transmission of the disease. Therefore, professional transmission of HIV-infection -, e. g. dental treatment of infected patients keeping the necessary cautions , - present minimal risk. The appropriate treatment of arai lesions of HIV-infected patients may help in maintaining their general health. ]

Lege Artis Medicinae

[The molecular genetics of Duchenne and Becker muscular dystrophy]

FODOR Flóra, PAPP Zoltán

[Duchenne muscular dystrophy, an X-linked inherited disease, is the most common among the severe muscular dystrophies, yet untreatable. lts secondary prevention, however, has become possible by the rapidly developing techniques of molecular biology. The authors describe the latest methods of DNA-diagnosis used, as well as the principles of setting up a diagnostic protocol.]

Lege Artis Medicinae

[The concept of the pathomechanism of ischaemic heart disease]

[The primary atherosclerotic plaque may remain unchanged in extent for a long time and, with the right size of stenosis, results in stable angina pectoris.]

Lege Artis Medicinae

[Family medicine, home care, family care]

ARNOLD Csaba

[General Practice as an independent speciality of medicine has a very special territory, the family care. The family care is a general wish of the society. This special care is continuously made in every fifth-sixth family. ln the author's practice in the autumn of 1989 113families and 16 lonely persons, in 1990 120 families and 18 lonely persons were controlled regularly at home. The family care, the family medicine needs special knowledge and skill. Minimal addicional technical, personal and financial support is requested, burt due to the special care activity the level of medical work increases and it becomes more humanistic, needs of hospitalization decreases and the plus expenditure refunds. Far the better evaluation of family care a more systematic undergraduate and postgraduate teaching and a special research work would be needed.]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Cases of inborn errors of metabolism diagnosed in children with autism

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[The role of sleep in the relational memory processes ]

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[A growing body of evidence suggests that sleep plays an essential role in the consolidation of different memory systems, but less is known about the beneficial effect of sleep on relational memory processes and the recognition of emotional facial expressions, however, it is a fundamental cognitive skill in human everyday life. Thus, the study aims to investigate the effect of timing of learning and the role of sleep in relational memory processes. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. Our results suggest that the timing of learning and sleep plays an important role in the stabilizing process of memory representation to resist against forgetting.]