[Painted plaster masks in the prison]
KOVÁCS Sándor
OCTOBER 07, 2024
Lege Artis Medicinae - 2024;34(9)
KOVÁCS Sándor
OCTOBER 07, 2024
Lege Artis Medicinae - 2024;34(9)
Szöveg nagyítása:
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Lege Artis Medicinae
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Lege Artis Medicinae
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Lege Artis Medicinae
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Lege Artis Medicinae
[The effectiveness of the fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) has been confirmed by several clinical trials in people with type 2 diabetes (T2DM). The aim of this study was to demonstrate the effectiveness of iGlarLixi treatment in improvement glycemic control in participants who were inadequately controlled on basal insulin using continuous glucose monitoring (CGM) data.
The primary endpoint of this 18-week, single-arm, open-label, phase 4 clinical trial was the change of blood glucose level time in range (TIR). The inclusion criteria were at least 3-year T2DM and 6-month treatment with basal insulin, HbA1c level ≥7.5% and ≤10% and fasting blood glucose level ≤7.8 mmol/l. CGM data recording was performed before the switch to iGlarLixi and at the 18th week. Dose titration of iGlarLixi was based on self-monitoring of blood glucose levels.
Overall 51 participants were treated with iGlarLixi and 34 participants had baseline and end-of-study CGM recordings (“per-protocol population”). The per-protocol population’s mean (SD) age was 66.4 (7.01) years and they have had T2DM for 16.6 (9.06) years at inclusion. The percentage of TIR increased from 71.8% (18.08) to 78.3% (12.36) (p=0.066), while the time above range (TAR) decreased significantly from 24.0% (18.96) to 9.9% (9.85; p<0.001). The percentage of time-below-range (TBR) increased from 4.2% (7.23) to 11.8% (13.48; p<0.001). The HbA1c level decreased from 8.4% (0.63) to 7.1% (0.91), and the fasting blood glucose levels also decreased.
This study confirmed the effectiveness of iGlarLixi using CGM data and provided numerous learnings for designing future CGM studies.]
Clinical Neuroscience
Face masks are crucial parts of personal protective equipment (PPE) to reduce the risk of respiratory infections. The COVID-19 outbreak has increased healthcare workers’ use of face masks. This study aimed to evaluate changes in cerebrovascular response among healthcare workers using surgical and N95 respirator masks. 90 healthcare workers: 30 wearing surgical masks, 30 wearing N95 respirators, and 30 without masks were included.
Effect of surgical mask and N95 respirator mask use on cerebrovascular reactivity
Wearing a face mask: effect on a doctor – patient relationship. Complicating factors and their compensations
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Clinical Neuroscience
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?2.
Clinical Neuroscience
Neuropathic pain and mood disorders in earthquake survivors with peripheral nerve injuries3.
Journal of Nursing Theory and Practice
[Correlations of Sarcopenia, Frailty, Falls and Social Isolation – A Literature Review in the Light of Swedish Statistics]4.
Clinical Neuroscience
[Comparison of pain intensity measurements among patients with low-back pain]5.
Journal of Nursing Theory and Practice
[Fear of Falling among Geriatric Patients: a Narrative Review]1.
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