Lege Artis Medicinae

[MOLECULARLY TARGETED BIOLOGICAL THERAPY IN THE TREATMENT OF SOLID TUMOURS]

LÁNG István, HITRE Erika

JANUARY 22, 2008

Lege Artis Medicinae - 2008;18(01)

[In part one of this article we reviewed the modern biological oncotherapy of breast cancer and colorectal cancer. Now we report on the biological therapies that target various kinase inhibitor pathways by monoclonal antibodies or by oral kinase inhibitors in gastrointestinal stromal tumours, pancreatic cancer, head and neck cancer, lung cancer and kidney cancer. Cell surface receptors (e.g., epidermal growth factor receptor in head and neck cancer) and ligands necessary for the growth of metastases (e.g., vascular endothelial growth factor in kidney cancer) can be blocked by specifically developed monoclonal antibodies. Small molecular weight oral kinase inhibitors, e.g., imatinib and sunitinib in gastrointestinal stromal tumour, erlotinib in pancreatic cancer, erlotinib and gefitinib in lung cancer, sunitinib and sorafenib in kidney cancer, sorafenib in hepatocellular cancer block intracellular signal transduction pathways. The mTOR inhibitor temsirolimus can be used in advanced renal cell carcinoma.]

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[“WHAT DO YOU THINK HAPPENS TO THOSE WHO RARELY GO OUTDOORS?”]

PLUHÁR F. Zsuzsanna, KOVÁCS Szilvia, PIKÓ Bettina, UZZOLI Annamária

[INTRODUCTION - The surrounding environment plays an important role in the development of psychosomatic symptoms. This study examines what children think of the consequences of not going outdoors for long periods. METHODS - Data were collected using the “draw-and-write” technique that besides the written answers allows children to express their thoughts in drawings. The questionnaire contained open-ended questions both on sociodemographic data and on the children’s notion of the relationship between environment and health or illness. Questionnaire submission was voluntary and anonymous. The study subjects were 9 to 11-year-old pupils (n=448, 44.6% boys, 55.4% girls) from six primary schools, two in Budapest, and one each in Pest, Jász-Nagykun-Szolnok, Csongrád and Békés counties. The primary schools were selected so as to represent various environmental locations, such as urban, town, suburban residential, area of blocks of flats. RESULTS - We found that all children agreed in that those who don't go outdoors for a long time will, in one way or another, get sick. Illnesses mentioned in the answers were classified in two categories, physical and mental. Physical health problems were further divided into four subcategories: symptoms (e.g., anaemia, pallor, fever, weak joints or bones); diseases; obesity; death. Mental health problems were divided into two subcategories: actual psychiatric diseases (e.g., depression) and symptoms, such as unhappiness, sadness, anger. CONCLUSIONS - We conclude that children in this study sample reckon the close connection between staying indoors for prolonged periods and the development of symptoms and disease.]

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