Lege Artis Medicinae

[In memoriam Prof. Dr. István Kiss (1952-2018)]

FARSANG Csaba, KAPÓCS Gábor, VÁLYI Péter, HOLLÓS Kata

JUNE 20, 2018

Lege Artis Medicinae - 2018;28(04-05)

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Lege Artis Medicinae

[Treatment of EGFR mutant lung adenocarcinoma after progression]

BOGOS Krisztina

[Precision medicine proposes the personalization of health services in order to make the best individual decisions about the interventions and treatments for the patient. Molecular genetic diagnostic tests help to select the appropriate therapy, so-called targeted therapy. In the case of extensive lung cancer with EGFR mutation, EGFR tyrosine kinase inhibitors are immediately applicable; they are very effective and can reach long-term remission of the disease. However, resistance mutation can develop during the treatment, which causes the progression of the disease; therefore change of therapy is needed. In our case, we show the possibility of targeted treatment beyond the progression, emphasizing the importance of detecting resistance mutation. ]

Lege Artis Medicinae

[Autopsy by Pencil – When Anatomy and Art Meet ]

CZIGLÉNYI Boglárka

Lege Artis Medicinae

[Oncophilosophy]

SINKÓ Dániel

[Combining oncology with philosophy, as seemingly two different disciplines, is an exciting task but the question arises as to why this is necessary. For thousands of years philosophers have been trying to find answers to the basic questions of being-existence, reality, death, morality but from the twentieth century we see less and less the daily significance of these. Are not “questions of existence” important or are they no longer relevant? We would like to believe they are not but there are situations where suddenly our existence is threatened and all our already gained life experiences are proved to be a failure…]

Lege Artis Medicinae

[The “room” for death in the family - dying as a role]

MÚJDRICZA Ferenc

[The Hungarian literature has quite ignored so far Noyes & Clancy’s Role Theory approach of dying. I present the outline and a critique of this conception, then lay the foundations of a reformed concept of the dying role. For the optimal and desired dying role is not one of peripherising and objectifying, rather one of placing the dying in the centre of the system of relations and roles radically restructuring under the influence of such role. The personality of the dying remains a true value in this central position. The reintegration of the dying can begin parallel to her disintegration by the progressive loss of her normal social roles (‘the loneliness of the dying’). Death can thus transform into a social phenomenon. I illustrate the argumentation on the central dying role with a case study using the method of a heterophenomenological, second-person character. By promoting the central and autonomous dying role, i.e. by the development of the necessary social role competences, or at least by publicising the thanatological knowledge, death can turn from an avoided, socially disintegrative taboo into a phenomenon that can strengthen the community even after the dying departed.]

Lege Artis Medicinae

[Konzerválószer-mentes krónikus kezelés glaucomában: a cseppkezelés okozta szemfelszín-betegség elkerülése]

HOLLÓ Gábor

[Ocular surface disease is a frequently seen condition in the elderly in the general po-pulation. In glaucoma patients the glaucoma-therapy related ocular surface disease is a particularly serious and common condition with complex pathogenenesis. Pre-servatives, most commonly benzalkonium chloride, employed in intraocular pressure lowering eye drops frequently cause or worsen ocular surface disease in glaucoma. The symptoms frequently undermine both the adherence to the prescribed intraocular pressure lowering drops and the vision related quality of life. Therefore the success of long-term glaucoma care in glaucoma-therapy related ocular surface disease is reduced. The current article summarizes the main pathogenetic aspects of glaucoma-therapy related ocular surface disease, and presents how to eliminate the main causative factor and normalize the ocular surface by using completely preservative free topical medication in glaucoma. ]

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HORVÁTH Gergely, KELETI Teodóra, MAKARA Mihály, UNGVARI S Gabor, GAZDAG Gábor

Background - With improving treatment options, more attention is being paid to the neurocognitive symptoms related to hepatitis C infection (HCI). While HCI-related neurocognitive impairments are frequently subclinical, they can influence patients’ quality of life and fitness to work. Objective - The aim of this study was to assess HCI patients’ neurocognitive functions and explore the correlations between disease variables and neurocognitive symptoms. Method - The study was conducted between January 1, 2013 and December 31, 2015. All patients with HCI were included in the study who were registered at the Hepatology Outpatient Clinic of Szent István and Szent László Hospitals, met inclusion criteria and volunteered to participate. Patients’ sociodemographic data and medical history were recorded in a questionnaire designed for the study. The 21-item Beck Depression Inventory was used to detect depressive symptoms. Six computerized tests were used to evaluate patients’ neuropsychological functions. Results - Sixty patients participated in the study. In comparison with general population standards, patients demonstrated poorer performance in several neurocognitive tests. Neuropsychological performance was correlated with age, sex, length of time since HCI diagnosis, Fibroscan score and the number of previous antiviral treatments. Conclusions - The study’s main finding is that compared to general population standards, patients with hepatitis C virus-related disease exhibit impaired neuropsychological functioning in visuomotor and visuospatial functions, working memory, executive functions, and reaction time. Executive functions and reaction time were the most sensitive indicators for the length and severity of disease. Deterioration in these functions has a major negative effect on work performance particularly in certain occupations.

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[“With Others, For Others...” An Interview with Surgeon Professor János Kiss by Elemér Nemesánszky]

NEMESÁNSZKY Elemér

Clinical Neuroscience

[In memoriam Professor Ervin Paraicz (1927-2012)]

GYÖRGY Ilona