Lege Artis Medicinae

[Immunohistochemical examination of the TGF-a and TNF-a content of breast cancer tissues and its prognostic relevance]

BEBŐK Zsuzsa1, NÉMETH Péter1, MÁRKUS Béla2, BRITTIG Ferenc3

FEBRUARY 24, 1993

Lege Artis Medicinae - 1993;3(02)

[ The tumour-biological roles of different growth factors and cytotoxic cytokines have been intensively studied. Expression of TGF-a and TNF-a was investigated in breast cancers using monoclonal anti-TGF-a and anti-TNF-a antibodies produced previously by our laboratory. Retrospective analysis was performed in 35 histopathological specimens of breast cancer patients clinically worked up and observed during 4-5 years after the surgical treatment. Correlations were analysed between TGF-a and TNF-a positivity and the TNM score, lymphnode metastases and the survival time of the patients. Corresponding to our previous experiments, anti-TGF-a and anti-TNF-a monoclonal antibodies are relevant both in native (cryostat) and routine formol-paraffin histological sections. According to the results of our retrospective study, TGF-a positive cases had a worse clinical prognosis, however, the TNF-a positive or double positive cases showed a better clinical prognosis during the long term observation. ]


  1. Pécsi Orvostudományi Egyetem Immunológiai és Biotechnológiai Laboratórium
  2. Markusovszky Kórház Sebészet
  3. Markusovszky Kórház Patológia Szombathely



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