Lege Artis Medicinae

[GLP-1 receptor agonists in the elderly]

WINKLER Gábor1

NOVEMBER 30, 2020

Lege Artis Medicinae - 2020;30(11)

DOI: https://doi.org/10.33616/lam.30.042

[According to current guidelines of type 2 diabetes, treatment, glucagon-like pep­tide (GLP) -1 receptor agonists (RAs) are primary suggested drugs of the early antidiabetic medication, just after the first an­ti­­diabetic metformin. However, more and more arguments support their optional application in old age diabetes. These include multi-target strong glycemic ef­fects, low risk of hypoglycaemia, proven cardio- and nephroprotective nature of long- and ultra long-acting derivatives, multifaceted be­neficial pleiotropic effects, as well as the appearence of their fixed combinations with analogue basal insulins effective in weight loss and lowering the blood pressure. This study reviews specific aspects of blood sugar lowering treatment in the elderly and the potential benefits of choosing GLP-1 RAs in this age group. While presenting data of relevant literature and own experiences it is emphasized, that these preparations can be used safely in long term also in this age group.]

AFFILIATIONS

  1. Észak-Közép-budai Új Szent János Kórház és Szakrendelô, Budapest, Miskolci Egyetem Egészségügyi Kar, Elméleti Egészségtudományi Intézet, Miskolc

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