Lege Artis Medicinae

[Diagnostic algorythm and treatment of bilateral malignant histiocytoma in everyday medical practice?]

VANYA Melinda, SZILI Károly, KELLERMAN Péter, KISS János, KAISER László, LAJOS György

FEBRUARY 05, 2016

Lege Artis Medicinae - 2016;26(01-02)

[OBJECTIVE - We report the rare case of a 47-year-old man with malignant fibrous histiocytoma, developing in the right tibia. CASE REPORT - We report a case of a 47 year-old man with chronic pain in his right leg. Magnetic resonance imaging and biopsy was performed. His pathological result was malignant fibrous histiocytoma. CONCLUSIONS - The management of malignant fibrous histiocytoma contains the combination of surgical procedure, chemotherapy and radiotherapy. The diagnosis and the total removal of the tumour is very difficult. ]



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[Familial hypercholesterolemia (FH) is a genetically heterogeneous disorders characterized by very high total cholesterol and low-density lipoprotein (LDL) cholesterol levels, and it accelerates the development of atherosclerosis and early cardiovascular disease. FH is most commonly caused by mutations in low-density lipoprotein receptor (LDLR) or apolipoprotein B-100 (APOB) genes. In rest of the cases the mutation is in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene. Previous studies have shown that rosuvastatin significantly reduces major cardiovascular events in high risk patients. The goal of our study was to investigate the lipid-altering efficacy of simvastatin or atorvastatin therapy compared with high-intensity rosuvastatin therapy in patients with FH and familiarity. Recent work has demonstrated the efficacy of high-intensity rosuvastatin therapy in enabling high-risk and very high-risk patients in lowering significantly plasma levels of total and LDL-cholesterol, which can subtantially affect major cardiovascular events in familial hypercholesterolemia.]

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