Lege Artis Medicinae

[Depression in Parkinson's disease, experiences with PK-MERZ infusion]

TAKÁTS Annamária1, BERGHAMMER Rita1, THOMKA Magdolna1, SZOMBATHELYI Éva1

JANUARY 29, 1992

Lege Artis Medicinae - 1992;2(01)

[It is accepted that depression is the most frequent psychopathological finding in Parkinson's disease. Recently has been proved that this depression is mostly of major nature according to DSM-III criteria. It may be due to the altered serotonin metabolism. A possible subgroup of Parkinson's disease has been suggested including the decreased serotonergic activity. So it seemed to be evident that drugs of serotonergic activity – like amantadine - may influence the depression in Parkinson's disease. 27 patients of Parkinson's disease with depression were given PK-Merz infusion. After the infusion treatment over 3 weeks – without changing the previous antiparkinson therapy – 18 of 27 patients improved, and this improvement was mathematically significant in all the depression scores. Amantadine results in inhibition of storage and endogenous release of biogen amines, that of serotonin, too, further the serotonin binding capaticy changes, as well.]

AFFILIATIONS

  1. Semmelweis Orvostudományi Egyetem Neurológiai Klinika

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