Lege Artis Medicinae

[DEFIANT]

MATOS Lajos1

FEBRUARY 24, 1993

Lege Artis Medicinae - 1993;3(02)

[The mean baseline left ventricular ejection fraction was 41%. The active agent increased early diastolic peak velocity by 0.06 ms at the mitral valve tip. The time-velocity integral increased by 1.2 cm. These indicate that early diastolic flow across the mitral valve is increased. An important factor appeared to be the decreased isovolumic relaxation time, which was shortened by 14.7 ms, whereas neither heart rate, blood pressure nor minute volume changed, so that a reduction in afterload could not play a role in the differences. During exercise, the nisoldipine group's power output increased by 12 W. These results suggest that nisoldipine-CC improves diastolic ventricular function and exercise performance in the study group. The effect is either due to the anti-ischaemic property of the drug or indicates an improvement in myocardial relaxation. ]

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  1. Országos Kardiológiai Intézet

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