Lege Artis Medicinae

[Clinical efficacy of daily once given netlimicin + ceftriaxon vs twice given netilmicin + ceftazidim in the treatment of severe nosocomial infections]

LUDWIG Endre1, MAGYAR Tamás1, LÁNYI Péter1, SZÉKELY Éva1

JULY 29, 1992

Lege Artis Medicinae - 1992;2(07)

[The combination of a beta-lactam and an aminoglycoside antibiotic is widely accepted in the treatment of severe nosocomial infections. In our study we compared two antibiotic regimens: the clinical efficacy of ceftriaxon + netilmicin once-a-day vs ceftazidim + netilmicin twice a-day. Patients: suffering from severe nosocomial infections and characterized by APACHE II, sepsis and injury scores. Dosage: Group | (n=30) – ceftriaxon 2 g iv. + netilmicin (2–7 mg/kg/bw) in one single dose. Group II (n=30) – ceftazidime 2 g bid + netilmicin (2–7 mg/kg/bw) divided in two doses. Laboratory parameters, netilmicin concentrations and cochlear function were checked regularly. 70% of pneumonias were cured or improved, while in the other infections (urinary tract, abdominal, soft tissue) the response rate was 90%. The lowest response rates were observed in Pseudomonas infections in both groups. Response rate in bacteremia was slightly higher in Group I. (5/7 vs 4/8). Four of 7 patients with Staphaureus infections failed to respond in Group II. Both methods of netilmicin administration proved to be safe. Both antibiotic regimens are effective in the treatment of severe nosocomial infections, however once-a-day administration is more convenient for the patients and saves cost.]


  1. Péterfy Sándor u. Kórház A-Belosztály Budapest



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