Lege Artis Medicinae

[CARDIOVASCULAR EFFECTS OF MENOPAUSAL HORMONE REPLACEMENT THERAPY]

PARAGH György, HARANGI Mariann

MARCH 21, 2006

Lege Artis Medicinae - 2006;16(03)

[The incidence of coronary heart disease in women rises sharply in the years following menopause. Hormone replacement therapy involves the administration of oestrogen, which provides postmenopausal symptom relief and reverses the changes in calcium and lipid metabolism. Moreover, oestrogen is also postulated to engage multiple mechanisms that defend against hypertension. Early observations suggested that postmenopausal women treated with hormone replacement therapy have significantly reduced cardiovascular risk. However, the results of primary and secondary prevention randomized clinical trials confirmed an increased cardiovascular risk rather than a beneficial effect of hormone replacement therapy in highrisk women. Controversy between results of observational and randomized clinical trials may partly be due to the unexplored genetic background. The authors summarize the effects of oestrogen on lipids, inflammation, haemostatic parameters, blood pressure and vascular wall. Genetic factors that modulate the effect of oestrogen as well as current recommendations on hormone replacement therapy after menopause in high risk women are also presented.]

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[INTRODUCTION - The risk of eating disorders is higher among young women where a slim body ideal dominates. In contrast, the male body ideal is based on the athletic type. The aim of the present study was to assess the relevance of the athletic ideal as a risk factor in certain professional subcultures of young men with respect to intensive workout and body dissatisfaction. These can be important risk factors of muscle dysmorphia in certain populations. METHOD - Body and eating attitudes, as well as workout habits of 1232 military and “general” college male students were studied using questionnaires. The Eating Disorder Inventory was used for all subjects, and general demographic data and information on their bodybuilding practice were also obtained. RESULTS - General college students had a significantly higher mean body mass index than military students (23.9 vs. 23.5 kg/m2). The prevalence of those engaged in bodybuilding was surprisingly high among the military students (64.5%). Comparisons between and within groups also showed significantly different scores on several subscales of the Eating Disorder Inventory. CONCLUSION - The findings suggest that male military college students tend to have protective factors against the psychopathological features of eating disorders.]

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