Lege Artis Medicinae

[By the Chronicler’s Eyes]

NEMESI Zsuzsanna

FEBRUARY 14, 2014

Lege Artis Medicinae - 2014;24(01-02)

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Lege Artis Medicinae

[Our body as an ecosystem, or the „brave new world” of metagenomics]

FALUS ANDRÁS, BARCS István, DUDA Ernő

[Micro-organisms (e.g. bacteria) are generally associated with diseases. We rarely consider that these organisms are living creatures, which pursue to survive and reproduce themselves. Obviously, they are dependent on and also have an active impact on their living environment. This interaction might be beneficial but also harmful - a situation they try to avoid. This complex network represents an extremely complicated multi-directional control, the disruption of which may result in serious diseases.]

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[The Eighth Church ]

NAGY Zsuzsanna

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[Effect of lactulose in minimal hepatic encephalopathy in cirrhotic patients]

LIPTÁK Judit

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[How to detect it? Dementia screening in primary care]

KÁLMÁN János, PAPP Edina, PÁKÁSKI Magdolna

[The early stage of dementia, the diagnostic and clinical importance of prodromal stages of dementia have been increasingly recognised in the past few years. Nowa - days, simple, rapid, easy to use cognitive screening tests are available, such as the recently developed Early Mental Test and the standardised Mini-Mental State Exami - nation, Clock Drawing Test, which could help general practicioners in the recommended regular dementia screening. The aim of this review is to help general practicioners understand the nature and importance of prodromal and manifest stages of dementia syndromes, and to summarise the characteristics, advantages and disadvantages of dementia screening tests that can be used in primary care. In addition, practical hints are also integrated regarding the diagnosis, screening and referral of persons with high risk for dementia.]

Lege Artis Medicinae

[The health prevention role of the forest]

SEREGI János, LELOVICS Zsuzsanna, BALOGH László, PAPP Lajos

[The government attaches great importance to the health conservation and protection role of the forest. National forestry manages the vast majority of the forest parks in the country, without their effort these popular places have been destroyed a long time ago. Forest parks attract crowds of people, jut in suburban forests of the capital city ten million people visit in each year. Beside the introduction of their purpose and function in health prevention, authors aimed to summary the consequences of doing sport in the nature, especially in the forest. The fact confirmed by medicine that 20-30 minutes long exercising multiplies cardiac function and cause at least a bit difficulty in breathing, improve the physical fitness in healthy people. The same is true for walking and hiking as well. It is well known that fresh air, sunshine, exercise in diverse environment have favorable effects on physical and mental conditions physically active lifestyle is an important factor in health.]

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Delirium due to the use of topical cyclopentolate hydrochloride

MAHMUT Atum, ERKAN Çelik, GÜRSOY Alagöz

Introduction - Our aim is to present a rare case where a child had delirium manifestation after instillation of cyclopentolate. Case presentation - A 7-year old patient was seen in our outpatient clinic, and cyclopentolate was dropped three times at 10 minutes intervals in both eyes. The patient suddenly developed behavioral disorders along with gait disturbance, and complained of visual hallucinations 20-25 minutes after the last drop. The patient was transferred to intensive care unit and 0.02 mg/kg IV. physostigmine was administered. The patient improved after minutes of onset of physostigmine, and was discharged with total recovery after 30 minutes. Conclusion - Delirium is a rare systemic side effect of cyclopentolate. The specific antidote is physostigmine, which can be used in severely agitated patients who are not responding to other therapies.

Clinical Neuroscience

[Effects of nasal provocation with a single-dose allergen on the explicit and implicit memory of physically active and inactive patients with ragweed allergy]

TOKODI Margaréta, CSÁBI Eszter, KIRICSI Ágnes, SCHULTZ Rebeka, MOLNÁR H Andor, ROVÓ László, BELLA Zsolt

[Background and purpose - Allergy is an endemic disease and has a considerable impact on the quality of life. This study aimed to measure the effect of active allergic rhinitis on memory functions of physically active and inactive patients with ragweed allergy. Methods - Memory functions were assessed before and after allergen exposure. Participants in both groups were provoked nasally with 30 IR/mL ragweed allergen in each nostril. Explicit memory was measured with story-recalling and implicit memory was investigated with reaction time task. Results - In neuropsychological assessments athletes performed significantly better, compared with the control group after allergen provocation in short-term and long-term memory functions. There was no difference between the groups in the implicit tasks. Athletes have achieved better results after provocation, comparing to the baseline test and the tests that measured short-term and long-term memory functions. Conclusion - Short-term disturbing factors, e.g. swollen nasal mucosa, sneezing, and watery eyes after provocation did have not caused deterioration in cognitive functions. A single-shot allergen in high doses have caused an increase of mental concentration, which was more pronounced in athletes.]

Clinical Neuroscience

[Retinal ganglion cell layer and visual function in patients with progressive external ophthalmoplegia caused by common mtDNA deletion]

FARZANEH Naghizadeh, VARGA Edina Tímea, MOLNÁR Mária Judit, HOLLÓ Gábor

[Aim - Mitochondrial (mt) disorders are metabolic conditions with multiorgan involvement, which often cause neuroophtalmological symptoms. The aim of the study was to investigate the relation between progressive external ophthalmoplegia (PEO), visual pathway and mitochondrial DNA (mtDNA) mutations in patients younger than 55 years of age. Methods - Five female patients (35 to 53 years of age) with mithochondrial disease were investigated. Automated threshold perimetry (Octopus G2 test), scanning laser polarimetry (GDx-VCC and GDx-ECC) and Fourier-domain optical coherence tomography (RTVue-100 OCT) were used in addition to detailed ophthalmological examination and evaluation of visually evoked potentials (VEP). Frequent mutations of the mtDNA were investigated in the patients’ blood and muscle samples. Results - PEO of various severity levels was found in all patients, using clinical tests. Genetic testing showed “common deletion” of mtDNA in all cases. For both eyes of 4 patients functional and structural ophthalmic tests had normal results. In one patient decreased visual acuity, reduced retinal nerve fiber layer thickness and prolonged L3 VEP latency time were found without optic disc damage and visual field deterioration. Conclusion - In 4 of our 5 patients with PEO due to common deletion of mtDNA retinal ganglion cells and visual function remained normal for a long period of life.]

Clinical Neuroscience

[SPECTRAL EEG-CHARACTERISTICS OF SUBCORTICAL ISCHEMIC BRAIN LESION- A CASE STUDY]

MOLNÁR Márk, CSUHAJ Roland, HORVÁTH Szabolcs, VASTAGH Ildikó, GAÁL Zsófia Anna, CZIGLER Balázs, BÁLINT Andrea, NAGY Zoltán

[Introduction - Although the EEG-changes caused by ischemic stroke are well known, data of the literature are rather ambiguous. The EEGfindings recorded in a patient with a unilateral subcortical ischemic lesion are evaluated with special emphasis related to the effect of the dynamics caused by eyes opening. Participants and methods - Data recorded from a patient (54 years old male with a completed stroke involving the frontal and parietal subcortical region in the left side) were compared to those of a control group (12 healthy age matched subjects). Absolute and relative frequency spectra, theta/beta quotients, the interaction index characterizing the effect of eyes opening and the symmetry index were calculated from the EEG recorded in eyes closed and eyes open conditions. Data of the patient were compared to those recorded in the control group on the basis of 95% confidance intervals. Results - Irrespective of the recording conditions the predominance of slow activity and the increase of theta/beta quotients were found in the absolute frequency spectra. The increase of beta1 and beta2 frequency bands following eyes opening on the side of the lesion were found to be less obvious than that seen on the intact side and that observed in the control group. With respect to the interaction index related to the side differences caused by eyes opening the change of the beta2 frequency band was found to be the most conspicuous. The symmetry index underscored the predominance of slow (delta, theta, alpha1) frequencies on the lesion side, and that of the fast (beta1, beta2) frequencies on the intact side in both recording conditions. Conclusions - Localized lesion of the white matter without cortical damage can cause the predominance of slow activity and decrease of the fast frequency bands on the side of the lesion which can be shown by the absolute frequency spectra and is revealed by the symmetry index. The lack of functional reactivity of the fast frequencies in the side of the lesion can clearly be seen in the change of relative spectra following eyes opening and on the basis of the calculation of the interaction index reflecting the dynamics of side differences.]

Journal of Nursing Theory and Practice

[Complications of wearing contact lenses]

MÉSZÁROSNÉ PINTÉR Katalin

[Aim of the study: The author seeks to identify the reasons why contact lenses can cause wearers to develop inflammation of the cornea. She also examines whether the development of this severe condition can be avoided. Sample and method: The study was conducted among contact lens-wearing inpatients at the Ophthalmology Department of the Szent Pantaleon Hospital and Clinic. A questionnaire designed by the author, consisting of closed-ended questions, was distributed to 18 patients. Results: All 18 of the patients used soft, monthly-replacement contact lenses. Ten persons wore the lenses for two weeks longer, and five persons for one week longer than prescribed. Five persons neglected to wash their hands before inserting and removing the lenses. Five persons were not in the habit of cleaning contaminants from the lens, and seven persons did not use fresh storage solution every day. Four persons used tap water for the care of the lenses. Five persons did not remove the lenses at night, and four inserted the lenses into red, inflamed eyes. With the exception of one person they did not take a break from wearing the lenses, and three persons possessed spectacles. Fourteen persons were not satisfied with the information received from the optician. Conclusions: All of the changes were due to bacterial complications that were attributable to unsatisfactory cleaning of the contact lenses. ]