Lege Artis Medicinae

[Boston Area Anticoagulation Trial for Atrial Fibrillation ]

MATOS Lajos1

AUGUST 31, 1993

Lege Artis Medicinae - 1993;3(08)

[With the exception of the first month, the prothrombin time was within the desired range for 83% of the study period. There were two "strokes" in the warfarin group (0.41%/year) and 13 in the control group (2.98%/year). The overall mortality rate was 2.25% in the warfarin group and 5.97% in the controls. Minor bleeding occurred in 38 patients on warfarin and 21 in the controls. Subsequent analysis of the control group according to whether and at what dose they were taking aspirin and the extent to which it protected against brain events showed that most brain events occurred among those taking 325 mg of aspirin per day (mean 3.9% per year). In the group taking neither aspirin nor warfarin, the incidence of "stroke" was 1.8% per year and in the warfarin-treated group it was 0.45%.]

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Lege Artis Medicinae

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