Lege Artis Medicinae

[Art in the Shade of the Plague]

NÉMETH István

MARCH 21, 2006

Lege Artis Medicinae - 2006;16(03)

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[THE EFFECT OF A BLACK RADISH PREPARATION ON THE REDOX HOMEOSTASIS IN INFLAMMATORY BOWEL DISEASE]

BLÁZOVICS Anna, KOVÁCS Ágota, SZÉKELY Edit, LUGASI Andrea

[INTRODUCTION - Natural antioxidants have been shown to indirectly act on signal transduction pathways and influence the induction of apoptotic genes in several ways. The black radish-based granules contain several bioactive components including isothiocyanates, flavonoids, vitamins and trace elements that can modify various molecular biological pathways. The aim of this study was to find out whether this preparation has an effect on the redox homeostasis of patients with inflammatory bowel disease. PATIENTS AND METHODS - Data from 32 middleaged patients (13 male, 19 female) with moderately active IBD were evaluated. Half of the patients (6 male, 10 female) received 0.2 g/day granules for 6 months in addition to regular treatment. Apart from other routine laboratory measurements, redox parameters including plasma reducing power, H-donor ability, free SH groups and IL-6, IL-1, TNFalpha, bile acids, cholesterol, triglycerides, red blood cell chemiluminescence and HbA1c level were determined. RESULTS - The black radish-based granules had no effect on the activity of inflammatory bowel disease. Beside a positive subjective judgement, bile acid levels had slightly increased and the values of redox parameters had decreased in the plasma by the end of the study period. The granules significantly diminished red blood cell chemiluminescence and moderately reduced the HbA1c-level. CONCLUSION - The results show that the granules rich in antioxidants and isothiocianate have a marked effect on the redox homeostasis of IBD patients even at low doses.]

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[Although it has no cure, bronchial asthma can be efficiently treated. The use of inhaled corticosteroids and, more recently, long-acting β2- agonist aerosols have produced extraordinary improvement in clinical outcomes, particularly in relation to chronic breathing complaints. Today the aim of pharmacotherapy is to achieve a symptom-free state by the combined administration of long-acting β2-agonist and inhaled corticosteroids in the form of aerosol.]

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