Lege Artis Medicinae

[Application of cytokine therapy in haematological diseases]

PÁLÓCZI Katalin1, PETRÁNYI Győző1

NOVEMBER 30, 1993

Lege Artis Medicinae - 1993;3(11)

[The clinical applications of cytokines playing a role in regulation of haematopoesis are summarized. The potential clinical use of human cytokines can arbitrarily be ramified into 4 strategies: 1. Stimulation of the immune response in order to enhance immunosurveillance of neoplasms. 2. Prevention of chemotherapy and tumour related immuno- and myelosuppression and improvement of non-specific mechanisms of host resistance. 3. Increase of maximum tolerated doses of conventional antitumour chemotherapeutic regimens. 4. Direct influence on tumour cell growth and differentiation via cytotoxic, cytostatic or regulatory mechanisms. Three interferons, almost 6 different interleukins, erythropoetin and three different colony stimulating factors are presented. The potential benefits of cytokines in haematological malignancies and also the difficulties in realising this potential are discussed. ]

AFFILIATIONS

  1. Országos Hematológiai, Vértranzfúziós és Immunológiai Intézet Transzplantációs és Immunterápiás Osztály Budapest

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