Lege Artis Medicinae

[Antineutrophil cytoplasmic autoantibodies and their pathogenic and diagnostic role in different diseases]

SZŰCS Gabriella1, SZEGEDI Gyula1

JULY 28, 1993

Lege Artis Medicinae - 1993;3(07)

[Antineutrophil cytoplasmic autoantibodies (ANCAs) are found in the circulation of patients with systemic vasculitic syndromes, including Wegener's granulomatosis, polyarteritis nodosa, Churg-Strauss syndrome, and other disorders within the spectrum of autoimmune diseases. ANCAs have specificity for different proteins in the cytoplasmic granules of neutrophils. Two major patterns of ANCA staining are observed by indirect immunofluorescence as say: cytoplasmic (C-ANCA) and perinuclear (P-ANCA). There is in vitro evidence that antineutrophil cytoplasmic autoantibodies are directly involved in the pathogenesis of antineutrophil cytoplasmic autoantibody-as sociated vasculitides. Antineutrophil cytoplasmic autoantibody titers may be useful in modulating treatment regimens.]

AFFILIATIONS

  1. Debreceni Orvostudományi Egyetem, III. Belklinika

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Lege Artis Medicinae

[Features of chronic alcoholic liver and pancreatic diseases]

NEMESÁNSZKY Elemér, DÖNGÖLŐ László

[The most common organ pathologies caused by alcohol abuse are chronic liver disorders and chronic pancreatitis. The incidence of these diseases has not yet been fully established but both are considered to be widespread in Hungary. Since there are forms which frequently occur without symptoms, clinicians might have difficulties in recognizing them. The diagnosis should be based on the results of laboratory screening tests and the findings of the physical examination. A variety of specific and functional tests should be performed. Morphologic damage of the organ can be assessed by analysing the tissuesample obtained by biopsy. In the course of the disease progression, well characterised clinical entities (syndromes) develop. Features of the most advanced stage are as follows: fibrosis of the gland causing functional insufficiency which manifests itself in marked laboratory and clinical alterations.]

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[Bronchological possibilities to treat the main airway stenosis]

STRAUSZ János, BÖLCSKEI Pál

[The review summerizes the recent broncholo gical possibilities to treat the main airway stenosis. The most of the patient have inoperable central endobronchial or endotracheal tumor. However these methods are of considerable palliativ value for recanalization of the main airway and these way for amelioration of the quality of life. The three methods: the LASER phototherapy, the afterloading irradiation and the stent implantation can be available yet in Hungary. ]

Lege Artis Medicinae

[Cutaneous symptoms and reactive arthritis in giardia lamblia infection]

RIESZ Tamás, VÁLYI-NAGY István, TEMESVÁRI Erzsébet, WINKLER Valéria, KASZÁS Ilona

[ The authors discuss reactive arthritis and cutaneous symptoms as two infrequent complications of giardiasis. The incidence of reactive arthritis and cutaneous symptoms in 569 patients with giardiasis with simultaneous characte risticbiliary and gastrointestinal manifestation was investigated. In the majority of cases, parasitic infection was detected from fresh (warm) bile or, in a smaller proportion of patients, from fresh stool. Nine patients presented with reactive arthritis, 59 with chronic urticaria, 17 with rosacea, 8 with prurigo nodularis, and 2 with erythema nodosum. In all cases, initial therapy consisted of metroni dazol (Klion), using a daily dose of 0.75-1.5 g for 10–15 days. Only those patients whose symptoms were eliminated or substantially diminished and whose duodenal aspirate and stool was devoid of the parasite one month following treatment were considered cured. Sixty seven patients remained Giardia positive after metronidazol treatment. A detailed description of the curative therapeutic combinations in the cases of 64 patients is presented in the paper. Despite repetitive and combination therapy, three patients remained Giardia positive and continued to present with the symptoms of the parasitic disease. The authors emphasize that in patients having cutaneous allergic symptoms, reactive arthritis, or erythema nodosum with simultaneous gastrointestinal symptoms (even of the gastroin testinal symptoms are mild or absent), biliary or gastrointestinal Giardia infection must be considered. ]

Lege Artis Medicinae

[Color doppler imaging of the eye and orbit]

BARTA Miklós, DANIEL A Merton , BARRY B Goldberg, ROBERTA M Sandy

[Color Doppler Imaging (CDI) has added new dimension to orbital sonography. The indications of this method are basically the vascular and neoplastic diseases of the eye and orbit. After demonstrating the scan technique and normal findings the authors present some pathologic entities, such as reversed flow in ophthalmic artery as a result of occlusion of the internal carotid artery, lack of blood flow in central retinal artery in another ocular ischemic syndrome and the blood flow within a choroidal melanoma. The authors' experience reveals that CDI with pulsed Doppler spectral analysis is a promising new technique for the evaluation of vascular structures of the normal orbit as well as ocular and orbital vascular pathology.]

Lege Artis Medicinae

[Cooperative new scandinavian enalapril survival study]

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[Mortality at the end of the 6th month of treatment was not different in the active versus placebo group (11% vs 9.9%). Irreversible circulatory failure led to death in 4.3% of the enalapril group; the same was 3.4% in the placebo group.]

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