Lege Artis Medicinae

[ALLHAT ]

MATOS Lajos

JANUARY 20, 2003

Lege Artis Medicinae - 2003;13(01)

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Lege Artis Medicinae

[4th International Congress of Pathophysiology]

ROSIVALL László, MONOS Emil

Lege Artis Medicinae

[SCIENTIFIC DIGEST]

Lege Artis Medicinae

[Randomized phase III study of gemcitabine-cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer]

REINDL Ildikó

Lege Artis Medicinae

[The Budapest PCI-programme in acute myocardial infarction]

ZÁMOLYI Károly

Lege Artis Medicinae

[Advances in sleep diagnostics]

HORVÁTH Róbert

[Despite the insufficient financial support, the number of the laboratories for sleep diagnostics and the examined patients are rising. The CPAP (Continuous Positive Airway Pressure) equipment playing the main role in the treatment of the obstructive sleep apnoe syndrome (OSAS) is recently available from three neurological centres (Budapest, Debrecen, Pécs). These centres can prescribe the machine as a ”model experiment” with 85% support given by the State Health Care. The increase of the number of the licensed hospitals is expected in the near future, the only condition is the polysomnography background. Differential diagnostics (narcolepsy, RLS, PLMS, sleepdependent laryngospasm, disorders of the circadian rhythm) and the follow-up of the CPAP using patients (indication, contraindication, compliance, CPAP pressure setting, CPAP therapy control) have been emphasized.]

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[THE ROLE OF ORAL ANTIDIABETIC AGENTS AND ACE INHIBITORS IN THE PREVENTION OF TYPE 2 DIABETES MELLITUS]

KEMPLER Péter

[Nowadays Type 2 diabetes is considered as a cardiovascular disease,. The cause of death among 80% of people with Type 2 diabetes is of cardiovascular origin, with the most common cause of death of myocardial infarction. Optimal solution would be the prevention of the disease and there are also some possibilities for intervention. The present paper summarises the role of antidiabetic agents and ACE inhibitors in the prevention of Type 2 diabetes mellitus. The incidence rate of Type 2 diabetes decreased by 36% using acarbose in the STOP NIDDM Trial and by 31% using metformin in the Diabetes Prevention Program. The rate of risk reduction regarding the incidence of Type 2 diabetes during the ALLHAT Study compared the subjects treated with thiazid diuretics among those treated with amlodipine was 25% by the end of the second year and 16% by the end of the fourth year, while the corresponding data for patients treated with lisinopril were 40% and 30%, respectively. The action of lisinopril on the better bioavailability of Insulin like growth factor I. (IGF-I) probably contributes to the beneficial effect of lisinopril on insulin sensitivity.]