LAM KID

[Bone metabolism and the 10-year probability of hip fracture and a major osteoporotic fracture using the country specific FRAX algorithm in men with type 2 diabetes mellitus]

PETHŐ Zsófia1, KULCSÁR-JAKAB Éva2, UGO Onyeka2, MOLNÁR Zsuzsanna2, KALINA Edit2, BALOGH Ádám3, PARAGH György4, ANTAL-SZALMÁS Péter2, KÁPLÁR Miklós4, BHATTOA HARJIT Pál2

FEBRUARY 20, 2014

LAM KID - 2014;4(04)

[Objectives: Was to evaluate 10-year probability of hip fracture and a major osteoporotic fracture using the FRAX algorithm, vitamin D status, bone mineral density (BMD) and biochemical markers of bone turnover in men over 50 years of age with type 2 diabetes (T2DM). We compared FRAX-predicted 10-year fracture probability, levels of 25-hydroxyvitamin D (25-OH-D), markers of bone turnover and bone mineral density at L1-L4 (LS) and femur neck (FN) in 68 men with T2DM with an age- and gender-matched group (n=68). The mean (range) age of the T2DM group was 61.4 (51-78) years. The prevalence of hypovitaminosis D (25-OH-D <75 nmol/L) was 59%. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.7 (0-2.8)% and 3.2 (0-8.5)%, respectively. BMD at the FN (0.974 gm/cm2 vs. 0.915 gm/cm2; p = 0.008) and LS (1.221 gm/cm2 vs. 1.068 gm/cm2; p < 0.001) was significantly higher in the T2DM cohort as compared to the healthy age matched males. 25-OH-vitamin D (67.7 nmol/L vs.79.8 nmol/L; p < 0.001), crosslaps (0.19 μg/L vs. 0.24 μg/L; p = 0.004) and osteocalcin (13.3 μg/L vs. 15.7 μg/L; p = 0.004) were significantly lower in the T2DM group. There was no difference in FRAX-related fracture probability between the two groups. The increased BMD in T2DM and the lack of inclusion of T2DM as a risk factor in the FRAX algorithm are probable explanations for the discordance between literature-observed and FRAX-related fracture probabilities.]

AFFILIATIONS

  1. Debreceni Egyetem, Általános Orvostudományi Kar, Reumatológiai Tanszék
  2. Debreceni Egyetem, Általános Orvostudományi Kar, Laboratóriumi Medicina Intézet
  3. Regionális Osteoporosis Centrum, Szülészeti és Nôgyógyászati Klinika
  4. Debreceni Egyetem, Általános Orvostudományi Kar, Belgyógyászati Intézet

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