Hypertension and nephrology

[Thomas G. Pickering (1940–2009) ]


JUNE 25, 2015

Hypertension and nephrology - 2015;19(03)



Further articles in this publication

Hypertension and nephrology

[Hungarian data about the ramipril based free or fixed doses combination therapy in connection with patients adherence]


[In the treatment of chronic diseases an appropriate therapeutic effect is only achieved with a long-term medication. Hypertension is no exception, because to achieve target blood pressure is of outstanding importance for the prevention of cardiovascular complications. The use of fixed drug combinations according to national and international data increases the patients adherence by 20 percent. In our article we present the one year patients adherence treated with ramipril and amlodipine free combination, ramipril/amlodipine fixed combination and ramipril/hydrochlorothiazide fixed combination in hypertension.]

Hypertension and nephrology

[A Practical Guidance to the Diagnostics and Treatment of Hyponatremia]

FORDÍTOTTÁK: Cseprekál Orsolya, KÓBOR Krisztina, KIS Éva, BRASNYÓ Pál, HARIS Ágnes, REUSZ György

Hypertension and nephrology

[Additions and Explanations to “A Practical Guideline to the Diagnostics and Treatment of Hyponatremia” ]

DEÁK György, HARIS Ágnes

Hypertension and nephrology

[The use of beta-blockers in Hungary 2007-2014 based on data from National Health Insurance]


[disease, various rhythm disturbances, migraine, essential tremor case, addition to the treatment of endocrine disorders caused tachycardia and also may be used in the treatment of systolic and diastolic heart failure. Using the National Health Insurance Fund (NHIF) database, we analyzed changes in the turnover of beta-blockers used domestically between 2007 and 2014. At the beginning of the period more than 50% was metoprolol as the used active ingredient, the end of the period, nebivolol became the most frequently assigned active agent betablocker (29%). Besides nebivolol the use of bisoprolol and carvedilol increased, among the “old” beta-blockers the use of pindolol, bopindolol continuously decreases, propranolol and sotalolol consumption stagnant after the initial small decrease. Metabolic syndrome, disorders of carbohydrate metabolism, in case of sleep apnea the advantage of nebivolol is accompanied by the status of enhanced sympathetic activity and consequent reduction of RAS activation. Vasodilation, inhibition of plaque formation, reduction of platelet aggregation and anti-proliferative effects of nebivolol are its unique characteristics in the beta-blocker group. Improves insulin sensitivity, thus it is not characterized by a long-term side effects that cause diabetes. Effective reduction in the central blood pressure with nebivolol is likely to reduce the risk of complications in stroke and other related central blood pressure. Therefore, if the recommendations of the international and domestic support for considering it is not surprising that the use of metoprolol reduced such a large extent and how nebivolol covered the significant majority of the entire domestic beta-blockers market. Carvedilol was before the second and currently has become the 3rd or 4th most frequently used beta blocker. The decrease in the use of metoprolol undoubtedly caused by change in the recommendations, getting out of the subsidized products, and the appearance of the above known, new effective drugs.]

Hypertension and nephrology

[I Have Brought a Case ]

KISS István

All articles in the issue

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Basic molecular genetics concepts. Basic concepts of non-traditional inheritance. The importance of Southern hybridisation and PCR techniques in the diagnosis of genetic diseases. The study of a gene in a specific disease. How to investigate inherited neurodegenerative diseases in children. Factors complicating the detection of a new transthyretin mutation (TTRAsp18Gly). The role of genetic testing in neurology. Structure of the genetic laboratory. Neurogenetic tests that can be performed in Hungary. Newer possibilities for genetic diagnosis of spinal muscular atrophy. Experience of prenatal testing. Neurological pathologies caused by trinucleotide repeat expansion. Molecular genetic diagnosis of Huntington's disease and its problems. Introduction of molecular genetic detection of fragile X disease in our country. Genetic aspects of von Hippel-Lindau disease. Advances in molecular genetics in inherited neuromuscular diseases. First domestic experience in molecular genetic diagnosis of Charcot-Marie-Tooth type 1 peripheral neuropathy. Heterozygote testing problems in Duchenne-Becker-type myopathies. Analysis of IQ and genotype in Duchenne and Becker muscular dystrophy. Primary mitochondrial myopathies. Non-primary mitochondriopathies based on aberrations of mtDNA. Our experience in processing Hungarian cases of Leber's hereditary optic neuropathy. Detection of mitochondrial deletions by PCR. Recent data on the genetic basis of some epilepsy syndromes. New insights into the genetics of epilepsy. Lysosomal patients in the ten-year patient database of our department. Biochemical diagnosis of inherited neuro-metabolic diseases. Neurogenetics in Germany. Prospect for gene therapy for the nervuous system and muscle. Preclinical research on gene therapy for Duchenne muscular dystrophy. Absence of apoe e4 allele in the neurofibrillary tangle subset of senile dementia. Mitochondrial DNA sequence variiaton of complex I genes in Parkinson's disease. Aging in epilepsy - a Hungarian multicentre study. Decrease in antiepileptic effect in pregnant women with epilepsy given a folic acid-containing multivitamin. Molecular genetic study of heredoataxia (SCAl, SCA2, SCA3, FA). Atrophy olivopontocerebellaris (Déjeriné-André-Thomas). Diagnostic problems. Hereditary Motor and Sensory Neuropathies (HMSN) in Southern Burgenland and Vicinity. Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. Expression of nitric oxide synthase (NOS) isoforms in skeletal muscle of patients with mitochondrial. Pedigree analysis of hungarian Rett syndrome girls. Epidemiological studies in a population with Huntington's disease in Western Transdanubia. The role of psychological factors in the counselling and care of individuals at risk for Huntington's disease. Lesch-Nyhan syndrome . Clinical analysis of type II spinal muscular atrophy. Familial scapuloperoneal syndrome and mitochondrial DNA defects. The use of rilutes in familial ALS. Addison's disease and symptoms - adrenoleukodystrophy Case report. On familial hemiplegic migraine. Examination of somatic mutations in cadaveric brain samples. EMG and genetic diagnosis of paramyotonia congenita. CTG-triplet expansion study in a three-generation family with myotonia dystrophy.

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[Ultrasound: present and future, an interview with professor Barry Goldberg]


[Ultrasound is a widely used and accepted diagnostic modality in the United States . There are many considerable differences between the practice of ultrasound in the United States and our country. Well-skilled sonographers are performing the examinations using abundant amounts of documentation. The main role of the physicians (sonologists) is to interpret the image. Radiologists and other physicians who are doing ultrasound are highly motivated to increase steadily the quality and quantity of ultrasound examinations. Their salary is related directly or indirectly to the number of studies performed. The medico-legal aspects of ultrasound (and of other imaging techniques) are also important. The ultrasound division of the Thomas Jefferson University Hospital in Philadelphia is considered to be the world 's largest ultrasound department. It is directed by Professor Barry B. Gold berg. He is widely known as a leading authority in the „ultrasound world" the author of more than 59 monographs and chapters of different textbooks of ultrasound , and also a pioneer of echocardiography. His first publication on ultrasouncl appearecl twenty-four years ago. During my visit in Philadelphia I had a chance to ask him some of my questions concerning present and future of ultrasound. ]