Hypertension and nephrology

[The role of sodium-glucose cotransporters in diabetic nephropathy]

HODREA judit1,2, BALOGH Dóra Bianka1, LÉNÁRT Lilla1,2, KŐSZEGI Sándor1,2, HOSSZÚ Ádám1,2, VANNAY Ádám2,3, WAGNER J. László4, REUSZ György2, SZABÓ J. Attila2,3, FEKETE Andrea1,2

SEPTEMBER 20, 2015

Hypertension and nephrology - 2015;19(04)

[Diabetic nephropathy is the main cause of chronic kidney disease affecting about one-third of type 2 diabetic patients. The exact pathomechanism is not known, therefore the treatment and the prevention is still unsolved. However appropriate glycemic control and lowering blood pressure significantly slow the progression of kidney damage these treatment options are still not enough to stop renal injury. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the newest drugs in the treatment of diabetes. By inhibiting the glucose reabsorption in the proximal tubules SGLT2 inhibitors lower blood glucose level and facilitate glucosuria. This paper summarizes the effect of SGLT2 inhibitors currently approved in Europe paying particular attention to their possible renoprotective effects.]

AFFILIATIONS

  1. MTA-SE, „Lendület” Diabétesz Kutatócsoport, Budapest
  2. Semmelweis Egyetem, I. Sz. Gyermekgyógyászati Klinika, Budapest
  3. MTA-SE, Gyermekgyógyászati és Nephrológiai Kutatócsoport, Budapest
  4. Semmelweis Egyetem, Transzplantációs és Sebészeti Klinika, Budapest

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