Hypertension and nephrology

[Hungarian Vasculitis Registry – results of the first five years]

HARIS Ágnes1, TISLÉR András2, ONDRIK Zoltán3, FILE Ibolya4, MÁTYUS János5, ZSARGÓ Eszter5, DEÁK György5, AMBRUS Csaba6,7

OCTOBER 20, 2018

Hypertension and nephrology - 2018;22(05)

[Launching the Hungarian Vasculitis Registry aimed to collect information about prevalence and outcome of our patients with ANCA-associated vasculitis, and treatment protocols of the disease. The on-line data collection has been developing dynamically since its initiation five years ago, presently 278 patients’ files are available. Patients’ mean age is 58.2±14.5 years, 62% are women; their disease is associated with c-ANCA positivity in 51% and p-ANCA in 49%. At diagnosis GFR was 24.6±21.6 ml/min/1,73 m2, that time 29%, during the total follow up 39% of the registered subjects needed dialysis. Renal replacement therapy could be discontinued in 23% of them. In cases with focal histological changes, also with upper respiratory tract and skin involvement dialysis was significantly less frequently necessary, which underlines the importance of early diagnosis. In induction therapy steroid was administered for 94% of the patients, 85% of them got cyclophosphamide, 59% was treated by plasmapheresis, 11% got rituximab. Maintenance treat ment contained steroid in 80%, per os cyclophosphamide in 23%, parenteral cyclophosphamide in 22%, furthermore 40% of the patients got azathioprin, 8 subjects got mycophenolate and 6 got methotrexate. Median follow up was 30 months (IQR 6-78), during which period 20% of the patients died, 5% got kidney transplantation, and 5% were lost to follow up. Median survival was 14.8 years, five years survival was 85%, and ten years survival was 70%. Long term survival in patients with c-ANCA vasculitis seemed better comparing to p-ANCA vasculitis, but when correcting by age this difference disappeared. Predictors of death were age and dialysis dependent renal failure. Relapses developed in 27% of patients, 28% of them presented in the first year, 21% suffered it after five years of care. Collected data by the Hungarian Vasculitis Registry shows our society’s successful professional activity. Our results are comparable to the published data in the literature, yet there are several areas in our care where further improvements are warranted in order to increase our patient’s survival and quality of life.]


  1. Szent Margit Kórház, Nefrológiai Központ, Budapest
  2. Semmelweis Egyetem, I. Sz. Belgyógyászati Klinika, Budapest
  3. Szegedi Tudományegyetem, Nefrológia és Hypertonia Centrum, Szeged
  4. Debreceni Egyetem, Klinikai Központ, Belgyógyászati Intézet, Nefrológia
  5. Uzsoki Utcai Kórház, III. Belgyógyászati-Nefrológiai Osztály, Budapest
  6. Szent Imre Egyetemi Oktatókórház, Hypertonia-Nefrológia Profil, Budapest
  7. Semmelweis Egyetem, II. Sz. Belgyógyászati Klinika, Geriátriai Tanszéki Csoport, Budapest



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