Hypertension and nephrology

[Association between the genetic polymorphism of heat-shock protein 72 and pediatric kidney diseases]

BÁNKI Nóra Fanni1,2, RUSAI Krisztina2, KÁROLY Éva3, SZEBENI Bea4, VANNAY Ádám4, SALLAY Péter2, REUSZ György2, TULASSAY Tivadar2,4, SZABÓ J. Attila2, FEKETE Andrea1

DECEMBER 08, 2012

Hypertension and nephrology - 2012;16(05)

[Recurring urinary tract infections (UTI) in childhood may result in chronic- and end-stage-renal-disease (ESRD), which leads to the initiation of dialysis and renal transplantation (NTx). Heat shock protein (HSP) 72 protects the kidney, whereas it refolds destroyed proteins and cells, and helps regenerating the renal tissue. The HSPA1B (1267)G allele is associated with lower HSP72 expression. This study assesses the role of HSPA1B A(1267)G polymorphism using PCR-RFLP in 103 children treated because of recurrent UTI, 26 children after NTx and 235 healthy controls. Clinical data were also evaluated. HSPA1B (1267)GG genotype and HSPA1B (1267)G allele occurred more frequently in the UTI (p=0.0001; CI: 1.378-2.68) and in the NTx (p=0.014; CI: 2.29-187.7) patient group than in the controls group, and were associated with a higher risk for scarring (p=0.012; CI: 0.33-1.00) and renal malformation (p=0.0072; CI: 1.623- 140.6). Our data indicate a relationship between the carrier status of HSPA1B (1267)G allele and the development of recurrent UTI and ESRD, raising further questions about the clinical and therapeutic relevance of these polymorphism.]

AFFILIATIONS

  1. SE-MTA, Lendület „Diabétesz” Kutatócsoport, Budapest
  2. Semmelweis Egyetem, I. Sz. Gyermekklinika, Budapest
  3. Szent Rókus Kórház, Baja
  4. SE-MTA, Nefrológiai Kutatólaboratórium, Budapest

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