Hypertension and nephrology

[Association between sleep disorders and inflammation among kidney transplant recipients]

FORNÁDI Katalin1,2, LINDNER Anett1,2, CZIRA Mária Eszter1, SZENTKIRÁLYI András1,3, LÁZÁR S. Alpár1, ZOLLER Rezső1, TURÁNYI Csilla1, VÉBER Orsolya1, NOVÁK Márta1,4, MUCSI István1,5,6, MOLNÁR Miklós Zsolt1,5,7

DECEMBER 22, 2011

Hypertension and nephrology - 2011;15(06)

[In patients on dialysis, the results of studies examining the association of sleep disorders and inflammation are controversial. We assessed the association between inflammatory markers and different sleep disorders in a large sample of kidney transplant recipients. In the cross-sectional study 100 randomly selected kidney transplanted patients underwent one-night polysomnography [“SLeep disorders Evaluation in Patients after kidney Transplantation (SLEPT) Study”] to diagnose obstructive sleep apnea (OSA) and periodic limb movement is sleep (PLMS). Athens Insomnia Scale (AIS) was used to assess the prevalence of insomnia. Socio-demographic information, data on medication, comorbidity and laboratory parameters were collected. Inflammatory markers such as Creactive protein (CRP), serum albumin, white blood cell count, interleukine-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were measured. The mean age was 51±13 years (43% female) and the prevalence of diabetes 19%. We found no significant difference in the levels of inflammatory markers between patients with OSA and PLMS versus (vs) patients without such disorders. Apnea-hypopnea index showed a significant association with white blood cell count (rho=0.23), and weak, non significant correlations with the other inflammatory markers (rho<|0.15|). PLM index showed weak, non significant correlations with all markers of inflammation (rho<|0.15|). The serum IL-6 level was significantly higher in patients with insomnia (AIS≥10) than in non-insomniacs [median (IQR): 3.2 (2.6-5.1) vs. 1.7 (1.2- 2.9) ng/l; p=0.009]. The levels of other inflammatory markers were similar between insomniacs and non-insomniacs. We did not find any association between the presence of objectively assessed sleep disorders and inflammatory markers in kidney transplant patients.]

AFFILIATIONS

  1. Semmelweis Egyetem, Magatartástudományi Intézet, Budapest
  2. Semmelweis Egyetem, Neurológiai Klinika, Budapest
  3. Institute of Epidemiology and Social Medicine, University of Muenster, Németország
  4. Dept. of Psychiatry, University Health Network, University of Toronto, Kanada
  5. Semmelweis Egyetem, Kórélettani Intézet, Budapest
  6. Dept. of Medicine, Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Kanada
  7. Harold Simmons Center for Chronic Disease Research & Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, Amerikai Egyesült Államok

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