Clinical Oncology

[Role of infl ammation in the carcinogenesis]

KOPPER László1, TÍMÁR József2

FEBRUARY 28, 2020

Clinical Oncology - 2020;7(1)

[Chronic infl ammation is an important promoter of the carcinogenesis of several cancer types and also an important contributor to mutagenicity beside the known carcinogens. Beside the continous regeneration of the affected epithelia chronic infl ammation provide a special microenvironment intra and extracellular environment which support malignant transformation and block emerging immune reactions. On the other hand, cancer is generating chronic infl ammation itself independent from its role in the carcinogenic process. It is due to cancer necrosis as well as to the production of infl ammatory cytokines. Cancer-induced infl ammatory reactions block antitumoral immune responses and continous monitoring of this process provide valuable clinical parameter of cancer progression.]

AFFILIATIONS

  1. Semmelweis Egyetem, 1. Sz. Patológiai és Kísérleti Rákkutató Intézet, Budapest
  2. Semmelweis Egyetem, 2. Sz. Patológiai Intézet, Budapest

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