Clinical Neuroscience

Utilization of acute vascular imaging and neurointervention for acute ischaemic stroke patients in 20 Hungarian stroke centers

POZSEGOVITS Krisztián1, SZABÓ Géza1, SZUPERA Zoltán2, NAGY Péter3, NÉMETH László4, KONDÁKOR István5, TUSA Csaba5, BERENTE László6, SALACZ Pál7, VÉCSEI László8, SAS Katalin8, SEMJÉN Judit9, NIKL János10, SZAPÁRY László11, KAKUK Anikó12, RÓZSA Csilla13, HORVÁTH Melinda13, IMRE Piroska14, KÖVES Ágnes15, BALOGH István16, MOLNÁR Sándor17, FOLYOVICH András18, AL-MUHANNA Nadim18, BÉRES-MOLNÁR Katalin Anna18, HAHN Katalin19, KRISTÓF Piroska20, SZÁSZ Attila Sándor20, SZŰCS Anna21, BERECZKI Dániel22

NOVEMBER 30, 2019

Clinical Neuroscience - 2019;72(11-12)

DOI: https://doi.org/10.18071/isz.72.0407

Background - Acute mortality rate of stroke in Hungary is significantly higher than in Western Europe, which is likely to be partially attributable to suboptimal treatment. Subjects and methods - We examined the use of acute vascular imaging and mechanical thrombectomy for acute ischaemic stroke patients. We collected data on 20 consecutive patients from Hungarian stroke centres before 31st August 2016. Results - Out of the reported 410 patients, 166 (40.4%) underwent CT angiography and 44 (10.7%) had mechanical thrombectomy. Conclusion - Only about 1/3 of acute ischaemic stroke patients eligible for thrombectomy actually had it. The underlying reasons include long onset-to-door time, low utilization of acute vessel imaging and a limited neuro­intervention capacity needing improvement.

AFFILIATIONS

  1. Department of Neurology, Dr. Kenessey Albert Hospital, Balassagyarmat
  2. Szent Imre Teaching Hostpital, Department of Neurology, Budapest
  3. Felsô-Szabolcsi Hospital, Department of Neurology, Kisvárda
  4. Kanizsai Dorottya Hospital, Department of Neurology, Nagykanizsa
  5. Balassa János Teaching Hospital of Tolna County, Department of Neurology, Szekszárd
  6. Dr. Bugyi István Hospital of Csongrád County, Department of Neurology, Szentes
  7. Péterfy Sándor Utcai Hospital, Department of Neurology, Budapest
  8. University of Szeged, Faculty of Medicine, Department of Neurology, Szeged
  9. Markhot Ferenc Teaching Hospital, Department of Neurology, Eger
  10. Szent Rafael Hospital of Zala County, Department of Neurology, Zalaegerszeg
  11. University of Pécs, Faculty of Medicine, Department of Neurology, Pécs
  12. Szabolcs-Szatmár-Bereg County Hospitals, Department of Neurology, Mátészalka
  13. Jahn Ferenc Dél-pesti Hospital, Department of Neurology, Budapest
  14. Csolnoky Ferenc Hospital, Department of Neurology, Veszprém
  15. Bajcsy-Zsilinszky Hospital, Department of Neurology, Budapest
  16. Kiskunhalasi Semmelweis Hospital, Department of Neurology, Kiskunhalas
  17. Soproni Erzsébet Hospital, Department of Neurology, Sopron
  18. Szent János Hospital and Észak-budai United Hospitals, Department of Neurology, Budapest
  19. Markusovszky Egyetemi Oktatókórház, Department of Neurology, Szombathely
  20. Hetényi Géza Hospital of Jász-Nagykun-Szolnok County, Department of Neurology, Szolnok
  21. National Institute of Clinical Neuurosciences, Budapest
  22. Semmelweis University, Faculty of Medicine, Department of Neurology, Budapest

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Background - Our objectives were to determine the differences in the vestibular evoked myogenic potential (VEMP) responses in patients diagnosed with early staged idiopathic Parkinson’s disease (PD) compared to the normal population and evaluate the vestibular system disorder causing balance-posture disorders. Second aim of this study was to investigate caloric test responses particularly in early staged PD compared to normal popu­lation. Material and methods - Thirty patients (14 females and 16 males; mean age, 60.6 ± 13.1 years) diagnosed with idiopathic PD and 28 healthy subjects (20 males and 8 females; mean age, 59.1 ± 6.4 years) were included. The patient and control groups were subdivided according to their age, gender and the patient group was subdivided according to onset time of the Parkinson symptoms, Hoehn-Yahr staging. The subgroups were compared for VEMP and caloric test responses. Results - There were no significant differences between the study and control groups for right and left VEMP measurements. Patients over 60 years and under 60 years did not show significant differences in terms of right and left mean VEMP measurements. However, P1 amplitude was significantly lower in patients over 60 years old (P = .004). Gender, disease duration, BERG balance scale and Hoehn-Yahr stage had no effect on the VEMP amplitudes. There was no significant correlation with the side of Parkinsonian symptoms to the side of canal paresis (P = .566) and the side on which no VEMP response was obtained in caloric test. Conclusion - VEMP responses were not different between PD and healthy subjects. VEMP P1 amplitude was decreased with age in PD group. Canal paresis and symptoms side were not statistically correlated in caloric test.

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[Trace elements are found in the living organism in small (trace) amounts and are mainly essential for living functions. Essential trace elements are in humans the chromium (Cr), cobalt (Co), copper (Cu), fluorine (F), iodine (I), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), zinc (Zn), and questionably the boron (B) and vanadium (V). According to the biopsychosocial concept, mental functions have biological underpinnings, therefore the impairment of certain neurochemical processes due to shortage of trace elements may have mental consequences. Scientific investigations indicate the putative role of trace element deficiency in psychiatric disorders such in depression (Zn, Cr, Se, Fe, Co, I), premenstrual dysphoria (Cr), schizophrenia (Zn, Se), cognitive deterioration/de­mentia (B, Zn, Fe, Mn, Co, V), mental retardation (I, Mo, Cu), binge-eating (Cr), autism (Zn, Mn, Cu, Co) and attention deficit hyperactivity disorder (Fe). At the same time, the excess quantity (chronic exposure, genetic error) of certain trace elements (Cu, Mn, Co, Cr, Fe, V) can also lead to mental disturbances (depression, anxiety, psychosis, cognitive dysfunction, insomnia). Lithium (Li), being efficacious in the treatment of bipolar mood disorder, is not declared officially as a trace element. Due to nutrition (drinking water, food) the serum Li level is about a thousand times less than that used in therapy. However, Li level in the red cells is lower as the membrane sodium-Li countertransport results in a Li efflux. Nevertheless, the possibility that Li is a trace element has emerged as studies indicate its potential efficacy in such a low concentration, since certain geographic regions show an inverse correlation between the Li level of drinking water and the suicide rate in that area. ]

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[The 123I-FP-CIT dopamine transporter SPECT imaging is a sensitive method to assess functional dopaminergic neuron terminals in the striatum. The method has also been available in Hungary for years. There are two main indications: (i) to help differentiate essential tremor from clinically uncertain Parkinsonism, including patients with early symptoms and (ii) to help differentiate dementia with Lewy bodies from Alzheimer’s disease. The aim of this paper is to review 123I-FP-CIT SPECT imaging based on international data/guidelines and our own experiences, thereby assisting nuclear medicine practitioners and neurologists.]

Clinical Neuroscience

The effect of psychiatric comorbidities and stress-coping strategies on perceived quality of life in migraine

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Purpose – Migraine is one of the most disabling primary headache conditions. We aimed to detect hidden symptoms of anxiety and depression and to survey stress-coping mechanisms and related quality of life in a large migraine population without any known psychiatric comorbidity. Method – 123 migraine patients (MG) and 66 healthy subjects (HC) completed the Beck Depression Inventory-II (BDI-II), the State and Trait Anxiety Inventory (S-STAI and T-STAI), the Stress and Coping Inventory (SCI) and the 36-Item Short Form Health Survey (SF-36). Results – MG patients reached significantly higher scores on the BDI-II and the T-STAI yielding previously undetected anxiety and depression symptoms. Significant differences were present on the SCI: higher stress scores and lower coping levels suggested impaired stress-coping strategies in migraine. MG patients achieved significantly lower scores on most of SF-36 subscales indicating lower perceived quality of life. Significant correlations were found between BDI-II, T-STAI, SCI scores and subscales of the SF-36. Conclusion – Unrecognized symptoms of anxiety and depression, as well as less effective stress-coping strategies might be related to the lower perceived quality of life in migraine. The screening of these symptoms might lead to more focused and efficient therapeutic strategies. Addressing stress management techniques could improve quality of life on the long-term.

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