Clinical Neuroscience

[Use of Nuredal (Niamide) in neuropsychiatry]

NAGY A. Tibor1, ZSADÁNYI Ottó1

JULY 01, 1965

Clinical Neuroscience - 1965;18(07)

[Authors report their experience with Nuredal (Niamide) in 52 patients. The effect on psychomotor inhibition, a core symptom of depression, was found to be indisputable and primary, and they suspect this to be an extension of the scope of psychotherapy. This potential is seen in the possibility of transforming reactive depressive disorders into neurotic depression.]


  1. Debreceni Orvostudományi Egyetem Ideg-és Elmegyógyászati Klinika



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Clinical Neuroscience

[Recording of pulsus-frequency and amplitude variation and its significance during posterior scala surgery]


[The most delicate neurosurgical interventions are those involving manipulation of the midline structures, supratentorially near the hypothalamus and infratentorially near the pons, medulla oblongata. Not only direct damage to these structures, but also temporary circulatory disturbances caused by pressure or traction may result in consequential oedema or atony, which may lead to a very serious condition of the patient, possibly death. While there are little or no signs of hypothalamic injury during surgery, even minor lesions of the posterior scala of the brain stem are immediately apparent in the form of vegetative reactions (in the anaesthetised patient), changes in pulse, blood pressure and respiration. It is the anaesthesiologist's task to monitor these very carefully and report them to the surgeon.]

Clinical Neuroscience

[About "aseptic" meningitis]


[Worming in aseptic meningitis should be considered in the presence of varying degrees of eosinophilia in the blood and CSF, especially in the presence of ascaris lumbricoides, cysticercosis and trichinellosis which may have spread to the nervous system. Meningitis tends to be partly toxic and partly neuroallergic. The CSF pattern of so-called sympathetic or concomitant meningitis, maintained by inflammatory foci, mainly purulent, of the body or brain, is always dependent on the development of the underlying disease. Changes in the latter are followed by changes in both the quantitative and qualitative cellular picture of the CSF and, to a lesser extent, in the protein levels. ]

Clinical Neuroscience

[Data for the isolation of midline subfrontal meningiomas]


[The author, reviewing the surgical descriptions of 20 cases of meningiomas with midline subfrontal and praesellar localization, found that in 5 cases the tumor was located on the lamina cribrosa and crista galli, in 3 cases it was located in the tuberculum sellae but also spread to the limbus sphenoidalis, and in 12 cases, the most frequent, it was located on the planum (jugum) sphenoidalis. He found the striking frequency of meningiomas adherent to the planum remarkable because in the publications on meningiomas this variant is not listed as a separate group, but is classified with the two former variants. - The correct analysis of the anamnesis, the osteo-, angio- and pneumographic images, and the justification for this is that while the site of adhesion of olfactory meningiomas is the os ethmoidale, that of planum meningiomas is the os sphenoidale, and while the former tends to destroy the base of the anterior scala, the latter tends to cause bone outgrowth. Although the tuberculum meningioma and planum meningioma are attached to the same bone and the limbus may be blurred, the former may show at most a slight bone lesion at the site of attachment, whereas the latter usually shows marked hyperostosis and specific bone outgrowth. On these grounds, he considers it justified to include planum meningioma as a separate variant alongside tuberculum meningioma and olfactory meningioma.]

Clinical Neuroscience

[Vascular traffic studies in neurological patients with special reference to Hallervorden-Spatz disease]


[Four out of 20 neurological patients (2 Friedreich's, 1 Wilson's, 1 gargoylism) were found to have abnormal overall iron metabolism by isotope analysis. In contrast, the general iron turnover of our Hallervorden-Spatz patients was found to be normal despite abnormal iron metabolism in the pallidum and substantia nigra. Iron storage in these formulas is continuous. These findings can be used in the pathogenesis of Hallervorden-Spatz disease. ]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

NÉMETH Klára Zsófia, SZÛCS Anna , VITRAI József , JUHÁSZ Dóra , NÉMETH Pál János , HOLLÓ András

We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

Clinical Neuroscience

Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias


In aging societies, the morbidity and mortality of dementia is increasing at a significant rate, thereby imposing burden on healthcare, economy and the society as well. Patients’ and caregivers’ quality of life and life expectancy are greatly determined by the early diagnosis and the initiation of available symptomatic treatments. Cholinesterase inhibitors and memantine have been the cornerstones of Alzheimer’s therapy for approximately two decades and over the years, more and more experience has been gained on their use in non-Alzheimer’s dementias too. The aim of our work was to provide a comprehensive summary about the use of cholinesterase inhibitors and memantine for the treatment of Alzheimer’s and non-Alzheimers’s dementias.

Lege Artis Medicinae

[Thiazide- or thiazide-like diuretics should be used in the treatment of patients with hypertension? Particularities of the situation in Hungary]


[Diuretics have remained the cornerstone of the antihypertensive treatment since their widespreading in the 1960s. According to the 2018 ESC/ESH Guidelines for the management of arterial hypertension, in the absence of evidence from direct comparator trials and recognizing that many of the approved single-pill combinations are based on hydrochlorothiazide, this drug and thiazide-like indapamide can be considered suitable antihypertensive agents. In the 2018 Hungarian guidelines indapamide is named as the most efficacious diuretic in the treatment of patients with hypertension. The aim of the publication is redefining thiazide- and thiazide-like diuretic use in the treatment of hypertensive patients, with particular attention to presently available hydrochlorothia­zide and indapamide, and their combination drugs in Hungary.]

Clinical Neuroscience

A cross-sectional study on the quality of life in migraine and medication overuse headache in a Hungarian sample: understanding the effect of headache characteristics

MAGYAR Máté , KÖKÖNYEI Gyöngyi , BAKSA Dániel, GALAMBOS Attila, ÉDES Edit Andrea , SZABÓ Edina , KOCSEL Natália , GECSE Kinga , DOBOS Dóra , GYÜRE Tamás , JUHÁSZ Gabriella , ERTSEY Csaba

Previous studies using generic and disease specific instruments showed that both migraine and medication overuse headache are associated with lower health-related quality of life (HRQoL). The aim of our study was to assess HRQoL differences in migraineurs and in patients with MOH and to examine how headache characteristics such as years with headache, aura symptoms, triptan use, headache pain severity and headache frequency are related to HRQoL. In this cross-sectional study 334 participants were examined (248 were recruited from a tertiary headache centre and 86 via advertisements). The Comp­rehensive Headache-related Quality of life Questionnaire (CHQQ) was used to measure the participants’ HRQoL. Data showed normal distribution, therefore beside Chi-squared test parametric tests (e.g. independent samples t-test) were used with a two-tailed p<0.05 threshold. Linear regression models were used to determine the independent effects of sex, age, recruitment method, headache type (migraine vs. MOH) and headache characteristics (presence of aura symptoms, years with headache, headache pain severity, headache frequency and triptan use) separately for each domain and for the total score of CHQQ. Significance threshold was adopted to p0.0125 (0.05/4) to correct for multiple testing and avoid Type I error. Independent samples t-tests showed that patients with MOH had significantly lower scores on all CHQQ domains than migraineurs, except on the social subscale. Results of a series of regression analyses showed that triptan use was inversely related to all the domains of HRQoL after correction for multiple testing (p<0.0125). In addition, headache pain severity was associated with lower physical (p=0.001) and total scores (p=0.002) on CHQQ subscales. Based on the results, different headache characteristics (but not the headache type, namely migraine or MOH) were associated with lower levels of HRQoL in patients with headache. Determining which factors play significant role in the deterioration of HRQoL is important to adequately manage different patient populations and to guide public health policies regarding health service utilization and health-care costs.

Journal of Nursing Theory and Practice

[Assessing Nurses’ Knowledge of Surgical Wound Care, Complications and Knowledge of Bandages]


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