Clinical Neuroscience

The modern concept of polyneuritis

MILLER Henry1

JANUARY 01, 1968

Clinical Neuroscience - 1968;21(01)

Our lack of detailed knowledge of the morbid histopathology of many forms of polyneuritis shows that this is a field where classical neuropathology can still make a major contribution to our understanding. In the toxic polyneuropathies, the experimental animal appears to offer the best hope of further clarification. But of all the possible approaches to the problem that of biochemistry is surely the most promising: the demonstration of a specific abnormality in Refsum's disease and also of genetically determined variations in individual patterns of drug excretion (Evans et al., 1960) suggest the possibility of exciting developments in the area that neurology shares with internal medicine, clinical biochemistry, and experimental pharmacology.

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  1. University of Newcastle

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