Clinical Neuroscience

[The illogical therapy]

SZIRMAI Imre1, SUREK György2, KAMONDI Anita2, MAGYAR Hedvig2, JUHÁSZ Csaba2

NOVEMBER 20, 1993

Clinical Neuroscience - 1993;46(11-12)

[Most of the causative pathological factors in ischemic cerebrovascular events cannot be recognized during the acute stage of the disease partly because of to the complexity of biophysical model of cerebral microcirculation, partly because the causative factors in this model cannot be confidently weighted. Clinical diagnoses on cerebral circulation disorders are based on the fundamental causes of the disorders. Evoking factors are hypotheses, consequently therapies are directed to hypotheses. The mathematical model of cerebral microcircualtion is mondeterministic. The interactions between vascular factors and blood fluidity can be roughly estimated. Judging the therapeutic efficacy is hindered by the nondeterministic disease model, the indefinite clinical clues, their individual variations, heterogenous diagnostic groups, and tendency of spontaneous restoration of symptoms. Non-specific drugs are used to treat cerebral ischemia, and trials making use of monotherapies have failed to change the life expectancy or the clinical course of ischemic patients. The acute stage of the disease cannot be defined and because of the incompleteness of clinical indicators „stroke prevention" appeares to be ambiguious. Therefore, the nature of the treatment of ischemic cerebrovascular disease is at present based on trial and error.]

AFFILIATIONS

  1. Semmelweis OTE Neurológiai Klinika, Budapest
  2. Pécsi Orvostudományi Egyetem Neurológiai Klinika, Pécs

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