Clinical Neuroscience

[Measurement of muscle action potential propagation velocity in clinical patient material]

HASZNOS Tivadar1, FENYŐ Egon1

FEBRUARY 01, 1966

Clinical Neuroscience - 1966;12(02)

[The authors investigated the propagation velocity of muscle action potentials in 53 normal individuals, 18 neurogenic lesions, 15 patients with myopathy and 2 patients with myasthenia. The muscle conduction velocity was assessed in the m. deltoideus, m. biceps brachii, m. flexor digiti V., m. tibialis anterior and m. quadriceps. Stimulation was performed with two needle electrodes in bipolar mode and recording with a concentric bipolar electrode. The muscle conduction velocity was 4.48 + 0.09 m/sec in the normal control group, 3.28 + 0.21 m/sec in neurogenic lesion and 3.07 + 0.18 m/sec in myopathy patients. The difference was highly significant in both groups (P < 0.001). The muscle conduction velocity within the neurogenic group was found to be the same in peripheral nerve lesion (3.29 = 0.33 m/sec) and anterior horn lesion (3.25 + 0.26 m/sec). In the neurogenic cases, we found a conduction velocity value below 3.5 m/sec in 68% of the clinically affected muscles. A conduction velocity below 3.5 m/sec was observed in 66.6% of myopathic patients. Conduction velocity values found in Duchenne-type dystrophia musculorum progressiva, dystrophya myotonic, thyrotoxic myopathy, myopathia tarda and polymyositis were significantly different from normal controls. In dystrophia musculorum progressiva in facioscapulo humeralis and limb girdle, the deviation from normal control was not significant. In myasthenia cases, muscle conduction velocity was normal (4.57 I 0.21 m/sec). The authors discuss the factors that may lead to a decrease in muscle conduction velocity in neurogenic and myogenic laesio. ]

AFFILIATIONS

  1. Budapesti Orvostudományi Egyetem Neurológiai Klinikája

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