Clinical Neuroscience

[Innervation of collagen fiber]

KISS Ferenc1, LÁNG Adolf1

OCTOBER 29, 1954

Clinical Neuroscience - 1954;7(05)

[The authors found characteristic nerve fibres on the surface of collagen fibres of various organs (glomus tympanicum, iris, gall bladder, kidneys, staple ligaments, ligamentum teres femoris, etc.) and in their fusion. The collagen fibres of the iris have been studied in albino rabbits and white goats, the other organs in humans. Our method of investigation was Lavrentjev's modified procedure in frozen sections.]


  1. Budapesti Orvostudományi Egyetem Anatómiai Intézetéből



Further articles in this publication

Clinical Neuroscience

[Additive to the pathology of the hypothalamus with particular reference to the problem of central death]


[In describing the medical history of a child who died of a hypothalamic tumor (infundibuloma), we attempted to provide a new type of multidimensional view of the hypothalamic synroma, breaking down the complex activity of the hypothalamus into functional units: autonomic reflex, autonomic regulatory, neuro-hormonal, sensory and motor, and psychic activity. We have discussed the localisability of functional units. A multidimensional view of the hypothalamic syndrome could become a great diagnostic aid. In our case, we have confirmed that an isolated injury to the hypothalamus may be the direct cause of the central form of death in the form of circulatory collapse.]

Clinical Neuroscience

[Traditions and development of Soviet neurosurgery]


[The intellectual isolation which had cut off our scientific life from Soviet science from the Great October Revolution until liberation led to the fact that the results of the developing science of neurosurgery could only be learned from Western literature, and obscured the achievements of Soviet surgeons in neurosurgery. The data that we have learned from the West have undoubtedly demonstrated the legitimacy of this new science and its strikingly wide potential for application. But its true significance can only now be understood, its future can only now be assessed, when we can process the Soviet neurosurgical literature now freely coming to us.]

Clinical Neuroscience

[Data for understanding regressive processes in gliomas]


[1. At least some of the circumscribed, sharp-edged necrosis seen in gliomas is not due to vascular occlusion. They may be of autoallergic origin. 2. The degradative cells of the perinecrotic chain are partly derived from histiocytes detached from the adventitia of the surrounding capillaries and partly glioma cells transformed into degradative cells. 3. In neither malignant nor benign gliomas is there a well-developed pyaglia membrane. 4. Degenerative processes do not play the same role in the spread of gliomas as in carcinomas. ]

Clinical Neuroscience

[Lectures and presentations of scientific meetings]

[A short summary of 4 scientific lectures.]

All articles in the issue

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Clinical Neuroscience

Retinal morphological changes during the two years of follow-up in Parkinson’s disease

ATUM Mahmut, DEMIRYÜREK Enes Bekir

The study aims to investigate the relationship between the progression of idiopathic Parkinson’s disease (IPD) and retinal morphology. The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and detailed neurological and ophthalmic examinations were performed at each follow-up. Unified Parkinson’s Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit. The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years, respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there was no significant difference between other visits (p=0.025, p=0.034, p> 0.05, respectively). There was no statistically significant difference in CMT between the two groups during the follow-up period (p> 0.05). Average and superior quadrant RNFL thicknesses were significantly thinning with the progression of IPD.

Hungarian Radiology

[Ogilvie’s syndrome associated with excretory urography]

SZÁNTÓ Dezső, SZŰCS Gabriella

[INTRODUCTION - The Ogilvie's syndrome is a disturbance of colonic innervation with parasympathic overreaction was assumed to be cause of large bowel segment spasm and poststenotic accumulation of gas. There is no distention in small intestine. CASE REPORT - In case of a 15 years old male during excretory urography six minutes after the administration of contrast material infusion Ogilvie's syndrome had occured. On 6, 12 and 18 min. abdominal plain film were demonstrated the acute spasm and poststenotic large bowel distention by air lumenogram phenomenon in the kidneys ambilateral renal tuberculosis by the whitening-like contrast opacity arising from centre calyx (pyelotubular reflux) in right side and by clubbing of calyces in left side (daisy flower sign). Not involved the small intestine. The colonic spasm and accumulation of gas lasted approximately 6 hours and ceased without medical aid. CONCLUSION - The Ogilvie's syndrome accompanying excretory urography is a toxic effect attributing to transient injury of peripheric neures and neurovisceral synapses.]

Hungarian Radiology

[Diagnostic and therapeutical possibilities in constipation]


[Constipation is a common gastrointestinal problem. The prevalence of symptoms related with constipation fluctuates from 3 to 20 per cent. Constipation occurs more frequently in the elderly people and in females and more frequent in case of inactivity and less fiber intake. Assesment of patients with severe constipation includes specialized investigations. Exclusion of primary organic causes has to be the first step, then metabolic, neurological and iatrogenic causes (such as medicament side effects, etc) have to be excluded. After these considerations special functional gastroenterological investigations are needed which contribute to the diagnosis and differential diagnosis of the cause of the constipation. Anorectal manometry, ballon expulsion test, defecography and colon transit studies allow us to distinguish between slow colon transit, colon inertia, different subtypes of outlet obstruction, and the constipation predominant irritable bowel syndrome. The evaluation of these specific studies leads to the exact diagnosis and appropriate treatement for their problem can be given to the patients, which always has to be individually planed in all cases.]


[Bone metabolism and body mass index in postmenopausal women]

TÁRCZY Csaba, TOLDY Erzsébet, SZERB János, VARGA László

[INTRODUCTION - In addition to several other causes constitutional factors play an important role in the development of osteoporosis.Various aspects of bone metabolism were examined to explain the differences in bone density between women with low and high body mass index (BMI). PATIENTS AND METHOD - One hundred and ninetytwo postmenopausal women were included in the study. Bone density was measured by forearm densitometry.To assess bone formation, serum osteocalcin levels were measured, while the rate of bone absorption was estimated from C-terminal telopeptide levels of collagen type I measured in urine and blood. RESULTS - The prevalence of osteoporosis was higher in women with low BMI than in those with normal or higher BMI. Bone metabolism - both formation and absorption - was increased in both groups, however, in women with low BMI this increase was more pronounced and bone metabolism tended to be shifted to absorption compared to patients with normal or higher BMI. CONCLUSION - Postmenopausal lean women have accelerated bone metabolism compared to obese women. This fact and the shift to absorption may be the main reasons for the higher frequency of osteoporosis found by densitometry in women with low BMI than in those with higher BMI.]

Lege Artis Medicinae


PAPP Zoltán, BORBÉLY Attila, ÉDES István

[Disturbances in ventricular relaxation may lead to the development of diastolic heart failure. The analysis of left ventricular endomyocardial biopsy specimens may help understand the underlying structural and functional changes. Such analyses have lead to the recognition that at the optimal sarcomere length of the Frank- Starling mechanism (i.e., at 2.2 μm), passive force values of the cardiomyocytes are significantly higher in individuals with diastolic heart failure than in healthy controls. As a probable explanation to this finding, increased expression of the stiffer N2B isoform of the myofilamental titin protein, at the expense of the more elastic N2BA titin isoform, has been recognized. Moreover, decreased phosphorylation of the contractile proteins was also suggested to contribute to the development of diastolic heart failure. These changes together, and along with an increase in extracellular collagen content, may greatly contribute to the relaxation disturbance observed in diastolic heart failure.]