Clinical Neuroscience

[Fine-structure analysis of muscle lesions in dystrophia muscularis progressiva]

KORÉNYI Both András1, LAPIS Károly1, GALLAI Margit1

OCTOBER 01, 1967

Clinical Neuroscience - 1967;20(10)

[Authors have used light and electron microscopy to examine material from a biopsy of a sister parathyroid patient with dystrophia musculorum progressiva. The fine structural alterations were consistent with those in the fine structure of neurogenic atrophies, denervated or otherwise damaged striated muscles. In dystrophia musculorum progressiva, the most common lesion affecting most muscle fibres is swelling of the sarcoplasmic reticulum system, which may be a morphological picture of the Richterich stage of decompensated enzyme synthesis. ]

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  1. Orvostovábbképző Intézet, Kórbonctani és Kórszövettani Tanszéke és Ideggyógyászati Tanszéke

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[In our presentation of 6 cases of "allergic" polyneuritis in children, we draw attention to the polymorphism of the clinical picture, the frequent involvement of the cranial nerve and the likely frequency of asymptomatic cases. The rare prolonged cases may be confused with heredodegenerative diseases. Their recognition is very important, because their prospects of recovery can be substantially improved by cortisone treatment. ]

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[In the context of an atypical status epilepticus consisting of partly generalized spike-wave and partly generalized de-synchronizing seizures, the relationship between the generalized spike-wave mechanism and the reticular awakening system is discussed. On the basis of the accumulated experimental data and clinical experience, as well as the lessons learned from our case study, we suggest that cortical inhibition of the facilitatory influence of the reticular waking system plays an essential role in the spike-wave mechanism. ]

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[Report]

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[The author reports on his experiences at the Psychiatric Research Institute in Prague in June 1967. ]

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