Clinical Neuroscience

[Experiences and conclusions from using Hirepin]

GOLDSCHMIDT Dénes1

APRIL 01, 1960

Clinical Neuroscience - 1960;13(04)

[The use of Chlorpromazine and Reserpine in psychiatric practice has become common in recent years. The efficacy of these drugs is considered to be at least equivalent to that of existing treatments. More recently, the use of Chlorpromazine and Reserpine in combination has become widespread. The tachycardia, obstipation and dry mouth effects of Chlorpromazine are well counterbalanced by the bradycardic, salivator and bowel motility-enhancing effects of Reserpine, and their psychic effect is synergistic (Deniker, 12). The literature on chlorpromazine and reserpine is almost incomprehensible: Deniker lists 315 works on the subject in his report to the 1957 Zurich Congress (12), and Kleinsorge and Rösner list 1867 in their 1958 monograph (25). Here, I would like to deal with Chlorpromazine and Reserpine (hereafter Chl. and R.) and one of the side effects of the combination of the two and one of the ways to avoid them, in the context of a new Hungarian drug combination, Hirepin.]

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