Clinical Neuroscience

[Efficacy of cinolazepam on insomnia generated under shift-work conditions]

KÖVES Péter1

SEPTEMBER 20, 1993

Clinical Neuroscience - 1993;46(09-10)

[The efficacy of cinolazepam (a benzodiazepine with middle half life time and light pharmacological potential) on insomnia generated under shift-work conditions was investigated, and shown to be an efficent hypnotic. Cinolazepam (daytime dose 20 mg, night dose 40 mg) improved significantly both sleep and awakening quality: there were no hangover effects, drug provoked intrasleep or early morning insomnia. During the time cinolazepam was administered drug tolerance was not observed. The structure of cinolazepam-induced sleep could be characterised by shortened sleep latency, increase of deep slow wave sleep, improvment of sleep continuity and unchange of REM sleep parameters both during night- and daytime.]

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  1. MH Budai Honvéd Kórház, Ideg- Elmeosztály

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