Clinical Neuroscience

[EFFECTS OF KETAMINE ON THE DEVELOPING CENTRAL NERVOUS SYSTEM]

VUTSKITS László1,2, GASCON Eduardo2,3, KISS Zoltán József2

MARCH 20, 2007

Clinical Neuroscience - 2007;60(03-04)

[Ketamine is a widely used drug in pediatric anesthesia practice, acting primarily through the blockade of the Nmethyl- D-aspartate (NMDA) type of glutamate receptors. A growing body of laboratory evidence, accumulated during the past few years, suggests that this drug could have potential adverse effects on the developing central nervous system. The goal of this short review is to give a brief synopsis of experimental work indicating ketamine-induced developmental neurotoxicity as well as to discuss potential limitations concerning extrapolation of these studies to clinical practice.]

AFFILIATIONS

  1. Department of Anesthesiology, Pharmacology and Intensive Care, University Hospital of Geneva, Geneva
  2. Department of Neuroscience, University of Geneva Medical School, Geneva
  3. Institut de Biologie du Développement de Marseille-Luminy, Marseille

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