Clinical Neuroscience

[Curing phantom pain with postcentral topectomy]

DEÁK György1, TÓTH Szabolcs1

JUNE 01, 1966

Clinical Neuroscience - 1966;19(06)

[The authors describe the course of their 2 patients with phantom limb pain treated with postcentral topectomy. One of their patients has been pain-free for 5 years and, to their knowledge, this is the second longest pain-free period after topectomy in the literature. The worsening of their other patient after a temporary improvement was partly related to inflammation in the stump after surgery - as a peripheral excitation - and partly to the late surgery of a patient who was alcoholic and consumed alkaloids. Based on the literature and on their own studies of patients, they argue that the essence of phantom pain is a disturbance of the body pattern that is more crucial than peripheral pathological stimuli, and that is an unusual and unpleasant experience. They recommend early cortical or subcortical surgery to eliminate the pathological body schema in cases of ineffective conservative or peripheral surgical treatment. ]


  1. Országos Idegsebészeti Tudományos Intézet



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Clinical Neuroscience

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[Authors have induced experimental porphyria in white rats. 13 animals with allyl isopropyl acetamide carbamide (Sedormid), 6 with griseofulvin (Likuden). This is the first successful experiment in the rat, having only been done in mice. The combined results of the two experiments: in all cases (19) very severe lesions were observed in the spinal cord and cortical neurons; spongiotic degeneration was observed in the white matter of the spinal cord of 16 animals, in the hippocampus and brainstem of 4 animals; in 2 cases demyelination was seen in the Burdach tracts of the spinal cord; finally, small haemorrhages were observed in the spinal grey horns of 3 animals. These experiments have demonstrated that the clinical signs described in experimental porphyria have a solid neurological basis. Their results are consistent with the neuropathological lesions reported in human disease, and thus their experiments are experimental evidence of human clinicopathological findings. ]

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Clinical Neuroscience

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