Clinical Neuroscience

[Corticosteroids and ACTH in neurology ]

LEHOCZKY Tibor1

JUNE 01, 1961

Clinical Neuroscience - 1961;14(06)

[Compile literature data on corticosteroids and ACTH, supplemented by your own experience. It covers those neurological diseases for which good or partial results can be achieved and those for which a definitive opinion has not yet been reached. It lists those conditions in which no therapeutic effect can be expected. Finally, it mentions the neurological complications of steroid therapy. ]

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  1. Fővárosi István Kórház Ideggyógyászati Osztálya

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Clinical Neuroscience

[The effects of alcohol on attention, from a forensic and accident psychology perspective]

PAP Zoltán

[ The aim of my study was to draw attention once again to the importance of so-called "mild intoxication" in causing traffic accidents. Based on the latest thinking, I wanted to point out the importance of compulsory blood alcohol testing and the assessment of relative and absolute limits in assessing fitness to drive, from a forensic, mental health and criminal law perspective. Based on the description of a hit-and-run traffic accident, I have attempted to psychologically analyse the mental state of a driver in a state of mild intoxication and to demonstrate that even 1.2% blood alcohol content can, under certain conditions, impair the ability to analyse, it can delay the speed of reaction, prolong the "time of the moment", reduce the number of distinct perceptions, and even, by "emptying the mind", cause a level of unconsciousness so great that the drunk person becomes totally incapable of driving.]

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[Histamine treatment of psychoses]

KORONKAI Bertalan, ORZÓY Róbert

[From our observations we have seen that the psychopathological target of histamine treatment is mainly affectivitas. In improved cases, a positive evolution of psychic settling preceded the treatment : in most cases, a temporary change in affectivity was observed. Emergence from autism, activation, improved cooperative skills, easier exploration, improvement of psychotherapeutic options are mostly transient results. There was a striking resolution of catatonic inhibition symptoms. With reduced tolerance, a more favourable outcome can be expected. Insulin was found to reduce tolerance, but in two of our cases it did not improve therapeutic options. Histamine treatment may therefore be effective in depressive symptom groups and in akinetic catatonic pictures. Since the results of treatment are generally not durable, its combination with other active treatments has favourable therapeutic potential. ]

Clinical Neuroscience

[Seven years of neurocare in Csongrád county]

ÁBRAHÁM István

[We do not know enough about the details of the work of rural mental health institutions, and in the absence of a comprehensive picture, there is no single law to harmonise their operations. In the following, I would like to report on the work of the Csongrád County Neurological Institute for almost seven years and contribute at least to some extent to clarifying the issue. ]

Clinical Neuroscience

[Behaviour of the cochleo vestibular artifact in patients with Barré - Lieou syndrome after physiotherapy after combined treatment.]

ALPÁR Pál

[Patients with inner ear hearing loss and dizziness had an X-ray examination of the cervical spine. We found positive findings in 12 cases. In addition to vasodilators, these patients were treated with spinal stretching and other physiotherapy. The patients were divided into 3 groups according to whether we found only cervical spondylosis or additionally organic vascular lesions and neurotic symptoms. Patients in the first group, especially those who were treated early, responded well to the complex treatment. In the other groups, the improvement was more modest. Our observation of a small number of cases also supports the association of inner ear disease with cervical spinal column lesions. ]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Clinical Neuroscience

[The role of sleep in the relational memory processes ]

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[A growing body of evidence suggests that sleep plays an essential role in the consolidation of different memory systems, but less is known about the beneficial effect of sleep on relational memory processes and the recognition of emotional facial expressions, however, it is a fundamental cognitive skill in human everyday life. Thus, the study aims to investigate the effect of timing of learning and the role of sleep in relational memory processes. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. Our results suggest that the timing of learning and sleep plays an important role in the stabilizing process of memory representation to resist against forgetting.]