Clinical Neuroscience

[Clinical experiences with Tofranil]


JULY 01, 1960

Clinical Neuroscience - 1960;13(07)

[1. The study reports 135 cases treated with Tofranil, 119 of them in the depression group and 16 in the schizophrenia group. 2. In endogenous depression, the treatment led to a complete cure in 68% of patients and to a substantial improvement in a further 12%. In psychoreactive depression, the cure was 45% and the substantial improvement 19%. In one case of suicide with lethal outcome, we emphasise the need for increased surveillance and careful selection of cases for outpatient treatment. 3. With the help of a timely initiated T. cure, the incipient depressive phases of several patients were reduced. One hypertensive patient's severe depression induced by chronic reserpine treatment was completely relieved by T. in four weeks. 4. The only psychiatric basis of endogenous depression, the pathological depressive state, T. - treated in about 4/5 of cases - is cured. The resolution of the pathological depressive state is accompanied not only by the disappearance of the vital depressive symptoms, but also by the disappearance of the secondary psychiatric symptoms of depression, often "abruptly", without any psychiatric intervention. 5. The results are considerably less favourable in cases where the depressive syndrome develops on the basis of organic disorders. 6. In 19 schizophrenic patients, T has been shown to be ineffective, with severe psychiatric complications including the onset of agitation. 7. Apart from the insignificant vegetative side-effects already described in other publications and the moderate eosinophilia observed in 37% of cases, the authors found no adverse somatic side-effects of T. and, in their opinion, no contraindication to the use of T. in depressive cases. In patients of the affective form, overdosage, or normal dosage in the case of special personal disposition, may lead to the occurrence of maniform agitation of varying degrees. In the case of a depressive syndrome or schizophrenic inhibition developing on an organic basis, the underlying disorder may be triggered by T. ]


  1. Budapest Főváros XIII. Ker. Tanácsa Róbert Károly körúti Kórháza Női Idegosztály



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