Clinical Neuroscience

[Beszámoló a fenilisopropilmetilpropinilaminnal végzett therapiás kísérletekről]

KARDOS György1, FÜREDI János1

AUGUST 01, 1967

Clinical Neuroscience - 1967;20(08)

[The authors conducted exploratory therapeutic trials in 46 patients with chronic schizophrenia using one of the new phenylalkylamine derivatives, phenylisopropylmethyl propinylamine HCl, synthesized by Knoll and colleagues. They conclude that thymoanalepticum, labelled E 250, is a drug that promises to be effective in chronic schizophrenics; at least in some cases. Since their chemosimilar experimental method, aimed at clinicopharmacological studies, has also led to therapeutic results, they conclude that better results can be obtained in many cases by individual and gradually increasing daily dosage, or by intermittent administration of the optimal dose, or by combined or alternating administration of E 250 with other psychotropic drugs. The new thymoanalepticum, like others, has been and is considered to be most effective mainly in endogenous depression and in exhaustive depression among psychogenic disorders. In addition, E 250 seems to be suitable for psychodiagnostic exploratory experiments and to support exploratory (analytic) and group psychotherapy. ]


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